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Acute infections in children are accompanied by oxidative modification of LDL and decrease of HDL cholesterol, and are followed by thickening of carotid intima-media.

Liuba, Petru (författare)
Lund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine
Persson, Jerker (författare)
Luoma, Jukka (författare)
visa fler...
Ylä-Herttuala, Seppo (författare)
Pesonen, Erkki (författare)
Lund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine
visa färre...
 (creator_code:org_t)
2003
2003
Engelska.
Ingår i: European Heart Journal. - 1522-9645. ; 24:6, s. 517-523
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • Background Atherosclerosis begins early in life. Infections might contribute to the pathogenesis of atherosclerosis. In this study, we investigated whether acute infections in children could alter the carotid wall morphology and the tipid profile. Methods Mean carotid intima-media thickness (IMT) was measured by high-resolution ultrasound in 28 hospitatised children (mean age: 5 2 years), who fulfilled the diagnostic criteria of acute infections (body temperature, >38 degreesC; C-reactive protein, >15 mg/ml, and clinical), and in 20 age- and gender-matched controls. Antibodies against oxidised tow-density lipoprotein (anti-oxLDL antibodies), as well as total and high-density lipoprotein cholesterol (HDL-C) were analysed in all children. The infection group was investigated both during the acute illness and 3 months after clinical recovery (post-infection). Results During the acute illness, the infection group had elevated anti-oxLDL antibodies and decreased HDL-C, as compared to those obtained at 3 months and in controls (p<0.05). These changes in the infection group were followed, at 3 months, by thickening of carotid intima-media. Those who received antibiotics during their acute illness had less carotid thickening than those who were not treated with antibiotics (p<0.05). Conclusion Acute infections in children seem to be accompanied by enhanced oxidative modification of LDL and by decrease in HDL-C. These lipid changes may be followed by thickening of carotid artery intima-media. These findings suggest that, in childhood, acute infections could be-associated with increased risk of atherosclerosis, and warrant further studies on this topic. (C) 2003 The European Society of Cardiology.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Kardiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)

Nyckelord

high-density lipoprotein
oxidised low-density lipoprotein
acute infection
carotid intima-media thickness

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Av författaren/redakt...
Liuba, Petru
Persson, Jerker
Luoma, Jukka
Ylä-Herttuala, S ...
Pesonen, Erkki
Om ämnet
MEDICIN OCH HÄLSOVETENSKAP
MEDICIN OCH HÄLS ...
och Klinisk medicin
och Kardiologi
Artiklar i publikationen
European Heart J ...
Av lärosätet
Lunds universitet

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