Sökning: id:"swepub:oai:lup.lub.lu.se:c2ecee56-125b-4b13-9cb2-637b51284dd7" >
Maternal dietary su...
Maternal dietary supplement use and development of islet autoimmunity in the offspring : TEDDY study
-
- Silvis, Katherine (författare)
- Medical College of Georgia
-
- Aronsson, Carin A. (författare)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups,Skåne University Hospital
-
- Liu, Xiang (författare)
- University of South Florida
-
visa fler...
-
- Uusitalo, Ulla (författare)
- University of South Florida
-
- Yang, Jimin (författare)
- University of South Florida
-
- Tamura, Roy (författare)
- University of South Florida
-
- Lernmark, Åke (författare)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups,Skåne University Hospital
-
- Rewers, Marian (författare)
- University of Colorado School of Medicine
-
- Hagopian, William (författare)
- Pacific Northwest Research Institute
-
- She, Jin Xiong (författare)
- Medical College of Georgia
-
- Simell, Olli (författare)
- Turku University Hospital
-
- Toppari, Jorma (författare)
- University of Turku
-
- Ziegler, Anette (författare)
- Klinikum rechts der Isar,Helmholtz Zentrum München
-
- Akolkar, Beena (författare)
- National Institute of Diabetes and Digestive and Kidney Diseases
-
- Krischer, Jeffrey (författare)
- University of South Florida
-
- Virtanen, Suvi M. (författare)
- Pirkanmaa Hospital District,Finnish National Institute for Health and Welfare,University of Tampere
-
- Norris, Jill M. (författare)
- University of Colorado
-
visa färre...
-
(creator_code:org_t)
-
- 2018-12-09
- 2019
- Engelska 7 s.
-
Ingår i: Pediatric Diabetes. - : Hindawi Limited. - 1399-543X .- 1399-5448. ; 20:1, s. 86-92
- Relaterad länk:
-
http://dx.doi.org/10...
-
visa fler...
-
https://europepmc.or...
-
https://lup.lub.lu.s...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Objective: We investigated the association between maternal use of vitamin D and omega-3 fatty acids (n-3 FAs) supplements during pregnancy and risk of islet autoimmunity (IA) in the offspring. Methods: The Environmental Determinants of Diabetes in the Young (TEDDY) Study is prospectively following 8676 children with increased genetic risk for type 1 diabetes in Finland, Germany, Sweden, and the United States. Blood samples were collected every 3 months between 3 and 48 months of age then every 6 months thereafter to determine persistent IA. Duration, frequency, and supplement dose during pregnancy were recalled by mothers at 3 to 4 months postpartum. Cumulative intakes of supplemental vitamin D and n-3 FAs were analyzed as continuous or binary variables. We applied time-to-event analysis to study the association between maternal supplement use and IA, adjusting for country, human leukocyte antigen-DR-DQ genotype, family history of type 1 diabetes and sex. Secondary outcomes included insulin autoantibodies (IAA) or glutamic acid decarboxylase (GADA) as the first appearing autoantibody. Results: As of February 2018, there were 747 (9.0%) children with IA. Vitamin D supplement intake during pregnancy (any vs none) was not associated with risk for IA (hazard ratio [HR] 1.11; 95% confidence interval [CI] 0.94, 1.31); neither was cumulative vitamin D supplement intake. Supplemental n-3 FA intake was similarly not associated with IA risk (HR: 1.19, 95% CI 0.98, 1.45). Similar lack of association was observed for either IAA or GADA as the first appearing autoantibody. Conclusions: The TEDDY cohort showed no evidence of benefit regarding IA risk for vitamin D or n-3 FA supplementation during pregnancy.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Nyckelord
- dietary supplements
- islet autoimmunity
- omega-3 fatty acids
- pregnancy
- vitamin D
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Silvis, Katherin ...
-
Aronsson, Carin ...
-
Liu, Xiang
-
Uusitalo, Ulla
-
Yang, Jimin
-
Tamura, Roy
-
visa fler...
-
Lernmark, Åke
-
Rewers, Marian
-
Hagopian, Willia ...
-
She, Jin Xiong
-
Simell, Olli
-
Toppari, Jorma
-
Ziegler, Anette
-
Akolkar, Beena
-
Krischer, Jeffre ...
-
Virtanen, Suvi M ...
-
Norris, Jill M.
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Endokrinologi oc ...
- Artiklar i publikationen
-
Pediatric Diabet ...
- Av lärosätet
-
Lunds universitet