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Proteomic profiling...
Proteomic profiling of human menisci from mild joint degeneration and end-stage osteoarthritis versus healthy controls
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- Paz-González, Rocío (författare)
- University of A Coruña
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- Turkiewicz, Aleksandra (författare)
- Lund University,Lunds universitet,Lund OsteoArthritis Division - Clinical Epidemiology Unit,Forskargrupper vid Lunds universitet,LU profilområde: Proaktivt åldrande,Lunds universitets profilområden,Lund University Research Groups,LU Profile Area: Proactive Ageing,Lund University Profile areas
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- Ali, Neserin (författare)
- Lund University,Lunds universitet,Lund OsteoArthritis Division - Clinical Epidemiology Unit,Forskargrupper vid Lunds universitet,LU profilområde: Proaktivt åldrande,Lunds universitets profilområden,Lund University Research Groups,LU Profile Area: Proactive Ageing,Lund University Profile areas
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- Ruiz-Romero, Cristina (författare)
- CIBER Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN),University of A Coruña
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- Blanco, Francisco J. (författare)
- University of A Coruña
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- Englund, Martin (författare)
- Lund University,Lunds universitet,Lund OsteoArthritis Division - Clinical Epidemiology Unit,Forskargrupper vid Lunds universitet,LU profilområde: Proaktivt åldrande,Lunds universitets profilområden,Lund University Research Groups,LU Profile Area: Proactive Ageing,Lund University Profile areas
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- Önnerfjord, Patrik (författare)
- Lund University,Lunds universitet,Molekylär skelettbiologi,Forskargrupper vid Lunds universitet,LU profilområde: Proaktivt åldrande,Lunds universitets profilområden,Molecular Skeletal Biology,Lund University Research Groups,LU Profile Area: Proactive Ageing,Lund University Profile areas
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(creator_code:org_t)
- 2023
- 2023
- Engelska.
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Ingår i: Osteoarthritis and Cartilage Open. - 2665-9131. ; 5:4
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Objective: To gain new insight into the molecular changes of the meniscus by comparing the proteome profiles of healthy controls with mild degeneration and end-stage osteoarthritis (OA). Method: We obtained tissue plugs from lateral and medial menisci of 37 individuals (central part of the posterior horn) classified as healthy (n = 12), mild signs of joint damage (n = 13) and end-stage OA (n = 12). The protein profile was analysed by nano-liquid chromatography-mass spectrometry using data-independent acquisition and quantified by Spectronaut. Linear-mixed effects modelling was applied to extract the between-group comparisons. Results: A similar protein profile was observed for the mild group as compared to healthy controls while the most different group was end-stage OA mainly for the medial compartment. When a pattern of gradual change in protein levels from healthy to end-stage OA was required, a 42-proteins panel was identified, suggesting a potential role in OA development. The levels of QSOX1 were lower and G6PD higher in the mild group following the proposed protein abundance pattern. Qualitative protein changes suggest lower levels of CYTL1 as a potential biomarker of early joint degradation. Conclusion: For future targeted proteomic approaches, we propose a candidate panel of 42 proteins based on gradually altered meniscal posterior horn protein abundance patterns associated with joint degradation.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Nyckelord
- Degeneration
- Meniscus
- Osteoarthritis
- Proteomics
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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