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Tolerability of non...
Tolerability of non-ergot oral and transdermal dopamine agonists in younger and older Parkinson’s disease patients : an European multicentre survey
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- Rizos, A. (författare)
- King's College Hospital
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- Sauerbier, A. (författare)
- King's College London,University Hospital of Cologne
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- Falup-Pecurariu, C. (författare)
- Transylvania University Brasov
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- Odin, P. (författare)
- Lund University,Lunds universitet,Restorative Parkinson Unit,Forskargrupper vid Lunds universitet,Lund University Research Groups,Central Hospital Bremerhaven
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- Antonini, A. (författare)
- University of Padova
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- Martinez-Martin, P. (författare)
- CIBER Enfermedades Neurodegenerativas (CIBERNED)
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- Kessel, B. (författare)
- King's College Hospital
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- Henriksen, T. (författare)
- Bispebjerg Hospital
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- Silverdale, M. (författare)
- Salford Royal NHS Foundation Trust
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- Durner, G. (författare)
- King's College Hospital
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- Ray Chaudhuri, K. (författare)
- King's College London,King's College Hospital
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(creator_code:org_t)
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- 2020-05-05
- 2020
- Engelska 5 s.
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Ingår i: Journal of Neural Transmission. - : Springer Science and Business Media LLC. - 0300-9564 .- 1435-1463. ; 127:6, s. 875-879
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://link.springe...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- In older patients with Parkinson’s disease (PD), the use of dopamine agonists (DA) has been limited due to uncertainties related to their tolerability in spite of potential gains with the advent of longer acting or transdermal therapies. Comparative real-life data addressing the tolerability of DA therapy across age ranges are currently sparse. This study addressed the tolerability (Shulman criteria, continued intake of DA therapy for at least 6 months) in PD patients across several European centres treated with long-acting and transdermal DA (Rotigotine skin patch, Ropinirole extended release, or Pramipexole prolonged release) as part of routine clinical care in younger and older PD patients. A medical record-based retrospective data capture and clinical interview-based follow-up survey of patients initiating or initiated on DA treatment (short and long acting) in a real-life setting. 425 cases were included [mean age 68.3 years (range 37–90), mean duration of disease 7.5 years (range 0–37), 31.5% older age (≥ 75 years of age)]. Tolerability was above 90% irrespective of age, with no significant differences between younger and older patients. Based on our findings, we suggest that long-acting/transdermal DA are tolerated in non-demented older patients, as well as in younger patients, however, with lower daily dose in older patients.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Allmänmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- General Practice (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Nyckelord
- Dopamine agonists
- Parkinson’s disease
- Tolerability
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Rizos, A.
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Sauerbier, A.
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Falup-Pecurariu, ...
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Odin, P.
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Antonini, A.
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Martinez-Martin, ...
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visa fler...
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Kessel, B.
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Henriksen, T.
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Silverdale, M.
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Durner, G.
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Ray Chaudhuri, K ...
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Allmänmedicin
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Neurologi
- Artiklar i publikationen
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Journal of Neura ...
- Av lärosätet
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Lunds universitet