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Leptospira interrog...
Leptospira interrogans outer membrane protein lipl21 is a potent inhibitor of neutrophil myeloperoxidase
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- Vieira, Monica L. (författare)
- Lund University,Lunds universitet,Infektionsmedicin,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Infection Medicine (BMC),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Instituto Butantan
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- Teixeira, Aline F. (författare)
- Instituto Butantan
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- Pidde, Giselle (författare)
- Instituto Butantan
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- Ching, Ana T.C. (författare)
- Instituto Butantan
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- Tambourgi, Denise V. (författare)
- Instituto Butantan
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- Nascimento, Ana Lucia T.O. (författare)
- Instituto Butantan
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- Herwald, Heiko (författare)
- Lund University,Lunds universitet,Host parasite interactions,Forskargrupper vid Lunds universitet,Lund University Research Groups
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(creator_code:org_t)
- 2018-03-01
- 2018
- Engelska 12 s.
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Ingår i: Virulence. - : Informa UK Limited. - 2150-5594 .- 2150-5608. ; 9:1, s. 414-425
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://www.tandfonl...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Leptospirosis is a widespread zoonotic and neglected infectious disease of human and veterinary concern that is caused by pathogenic Leptospira species. After entrance in the host, pathogenic leptospires evade the host natural defense mechanisms in order to propagate and disseminate to multiple organs. Myeloperoxidase is an enzyme stored in neutrophils azurophilic granules, and is released upon neutrophil activation to produce mainly hypochlorous acid, a strong oxidant and potent antimicrobial agent. In the present investigation, we studied the modulation of myeloperoxidase activity by L. interrogans serovar Copenhageni. We show that leptospires and their culture supernatants are able to inhibit both peroxidase and chlorination activities of myeloperoxidase, without interfering with neutrophil degranulation. By leptospiral outer membrane protein extraction and fractionation, we identified the proteins LipL21 and LipL45 as myeloperoxidase inhibitors, constituting new Leptospira virulence factors. Accordingly, we propose a function for the protein LipL21, one of the most expressed leptospiral outer membrane proteins. Our results show a novel innate immune evasion mechanism by which leptospires interfere with the host response in order to cope with the host oxidative stress and efficiently achieve dissemination and colonization.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
Nyckelord
- Host-pathogen interactions
- Immune evasion
- Innate immunity
- Leptospira
- Leptospirosis
- Myeloperoxidase
- Neutrophils
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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