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Training pathologis...
Training pathologists to assess stromal tumour-infiltrating lymphocytes in breast cancer synergises efforts in clinical care and scientific research
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- Ly, Amy (author)
- Massachusetts General Hospital
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- Garcia, Victor (author)
- United States Food and Drug Administration
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- Blenman, Kim R M (author)
- Yale University
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- Ehinger, Anna (author)
- Lund University,Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Patologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Pathology, Lund,Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Region Skåne
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- Elfer, Katherine (author)
- United States Food and Drug Administration
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- Hanna, Matthew G (author)
- Memorial Sloan-Kettering Cancer Center
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- Li, Xiaoxian (author)
- Emory University
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- Peeters, Dieter J E (author)
- Antwerp University Hospital,Sint-Maarten Hospital
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- Birmingham, Ryan (author)
- Emory University,United States Food and Drug Administration
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- Dudgeon, Sarah (author)
- Yale University
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- Gardecki, Emma (author)
- United States Food and Drug Administration
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- Gupta, Rajarsi (author)
- Stony Brook University
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- Lennerz, Jochen (author)
- Massachusetts General Hospital
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- Pan, Tony (author)
- Emory University
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- Saltz, Joel (author)
- Stony Brook University
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- Wharton, Keith A (author)
- Roche Tissue Diagnostics
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- Ehinger, Daniel (author)
- Lund University,Lunds universitet,Patologi, Malmö,Forskargrupper vid Lunds universitet,Forskningsgrupp Lungcancer,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Bröst/lungcancer,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Pathology, Malmö,Lund University Research Groups,Research Group Lung Cancer,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Breast/lungcancer,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Breast/lung cancer,Skåne University Hospital
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- Acs, Balazs (author)
- Karolinska Institutet,Karolinska Institute,Karolinska University Hospital
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- Dequeker, Elisabeth M C (author)
- Catholic University of Leuven
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- Salgado, Roberto (author)
- Ziekenhuis Netwerk Antwerpen (ZNA)
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- Gallas, Brandon D (author)
- United States Food and Drug Administration
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(creator_code:org_t)
- 2024
- 2024
- English.
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In: Histopathology. - 0309-0167 .- 1365-2559. ; 84:6, s. 915-923
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Abstract
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- A growing body of research supports stromal tumour-infiltrating lymphocyte (TIL) density in breast cancer to be a robust prognostic and predicive biomarker. The gold standard for stromal TIL density quantitation in breast cancer is pathologist visual assessment using haematoxylin and eosin-stained slides. Artificial intelligence/machine-learning algorithms are in development to automate the stromal TIL scoring process, and must be validated against a reference standard such as pathologist visual assessment. Visual TIL assessment may suffer from significant interobserver variability. To improve interobserver agreement, regulatory science experts at the US Food and Drug Administration partnered with academic pathologists internationally to create a freely available online continuing medical education (CME) course to train pathologists in assessing breast cancer stromal TILs using an interactive format with expert commentary. Here we describe and provide a user guide to this CME course, whose content was designed to improve pathologist accuracy in scoring breast cancer TILs. We also suggest subsequent steps to translate knowledge into clinical practice with proficiency testing.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
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- By the author/editor
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Ly, Amy
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Garcia, Victor
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Blenman, Kim R M
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Ehinger, Anna
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Elfer, Katherine
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Hanna, Matthew G
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show more...
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Li, Xiaoxian
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Peeters, Dieter ...
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Birmingham, Ryan
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Dudgeon, Sarah
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Gardecki, Emma
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Gupta, Rajarsi
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Lennerz, Jochen
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Pan, Tony
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Saltz, Joel
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Wharton, Keith A
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Ehinger, Daniel
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Acs, Balazs
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Dequeker, Elisab ...
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Salgado, Roberto
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Gallas, Brandon ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Histopathology
- By the university
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Lund University
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Karolinska Institutet