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Pressurized DNA sta...
Pressurized DNA state inside herpes capsids-A novel antiviral target
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- Brandariz-Nuñez, Alberto (författare)
- University of Illinois at Urbana-Champaign
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- Robinson, Scott J (författare)
- University of Illinois at Urbana-Champaign
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- Evilevitch, Alex (författare)
- Lund University,Lunds universitet,Virus biofysik,Forskargrupper vid Lunds universitet,Virus Biophysics,Lund University Research Groups,University of Illinois at Urbana-Champaign
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(creator_code:org_t)
- 2020-07-23
- 2020
- Engelska.
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Ingår i: PLoS Pathogens. - : Public Library of Science (PLoS). - 1553-7374. ; 16:7
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Abstract
Ämnesord
Stäng
- Drug resistance in viruses represents one of the major challenges of healthcare. As part of an effort to provide a treatment that avoids the possibility of drug resistance, we discovered a novel mechanism of action (MOA) and specific compounds to treat all nine human herpesviruses and animal herpesviruses. The novel MOA targets the pressurized genome state in a viral capsid, "turns off" capsid pressure, and blocks viral genome ejection into a cell nucleus, preventing viral replication. This work serves as a proof-of-concept to demonstrate the feasibility of a new antiviral target-suppressing pressure-driven viral genome ejection-that is likely impervious to developing drug resistance. This pivotal finding presents a platform for discovery of a new class of broad-spectrum treatments for herpesviruses and other viral infections with genome-pressure-dependent replication. A biophysical approach to antiviral treatment such as this is also a vital strategy to prevent the spread of emerging viruses where vaccine development is challenged by high mutation rates or other evasion mechanisms.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
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- art (ämneskategori)
- ref (ämneskategori)
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