Sökning: id:"swepub:oai:lup.lub.lu.se:c84dd260-b230-45f7-849c-d236d45300dc" >
Predictors of deter...
Predictors of deterioration of lung function in cystic fibrosis.
-
- Schaedel, Charlotta (författare)
- Lund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine
-
- de Monestrol, I (författare)
- Karolinska Institutet
-
- Hjelte, L (författare)
- Karolinska Institutet
-
visa fler...
-
- Johannesson, Marie (författare)
- Uppsala universitet,Institutionen för kvinnors och barns hälsa,Övrig pediatrisk forskning/Nordvall
-
- Kornfält, Ragnhild (författare)
- Lund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine
-
Lindblad, A (författare)
-
Strandvik, B (författare)
-
- Wahlgren, Lars (författare)
- Lund University,Lunds universitet,Statistiska institutionen,Ekonomihögskolan,Department of Statistics,Lund University School of Economics and Management, LUSEM
-
- Holmberg, Lars (författare)
- Lund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine
-
visa färre...
-
(creator_code:org_t)
- 2002-05-03
- 2002
- Engelska.
-
Ingår i: Pediatric Pulmonology. - : Wiley. - 8755-6863 .- 1099-0496. ; 33:6, s. 483-491
- Relaterad länk:
-
http://www.ncbi.nlm....
-
visa fler...
-
http://dx.doi.org/10...
-
https://lup.lub.lu.s...
-
https://doi.org/10.1...
-
https://urn.kb.se/re...
-
http://kipublication...
-
visa färre...
Abstract
Ämnesord
Stäng
- The severity of lung disease in cystic fibrosis (CF) may be related to the type of mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, and to environmental and immunological factors. Since pulmonary disease is the main determinant of morbidity and mortality in CF, it is important to identify factors that can explain and predict this variation. The aim of this longitudinal study of the whole Swedish CF population over age 7 years was to correlate genetic and clinical data with the rate of decline in pulmonary function. The statistical analysis was performed using the mixed model regression method, supplemented with calculation of relative risks for severe lung disease in age cohorts.The severity of pulmonary disease was to some extent predicted by CFTR genotype. Furthermore, the present investigation is the first long-term study showing a significantly more rapid deterioration of lung function in patients with concomitant diabetes mellitus. Besides diabetes mellitus, pancreatic insufficiency and chronic Pseudomonas colonization were found to be negative predictors of pulmonary function. In contrast to several other reports, we found no significant differences in lung function between genders. Patients with pancreatic sufficiency have no or only a slight decline of lung function with age once treatment is started, but an early diagnosis in this group is desirable.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
Nyckelord
- Cystic Fibrosis : physiopathology
- Cystic Fibrosis : surgery
- Cystic Fibrosis Transmembrane Conductance Regulator : genetics
- Disease Progression
- Female
- Human
- Longitudinal Studies
- Lung : physiopathology
- Male
- Lung Transplantation
- Mutation
- Predictive Value of Tests
- Regression Analysis
- Support
- Risk Factors
- Non-U.S. Gov't
- Cystic Fibrosis : microbiology
- Preschool
- Child
- Alleles
- Adult
- Adolescence
- MEDICINE
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
Hitta via bibliotek
Till lärosätets databas