SwePub
Sök i LIBRIS databas

  Utökad sökning

id:"swepub:oai:lup.lub.lu.se:ca6e18f0-8052-489a-b7cc-7c04728ddb19"
 

Sökning: id:"swepub:oai:lup.lub.lu.se:ca6e18f0-8052-489a-b7cc-7c04728ddb19" > CD137 (4-1BB) costi...

CD137 (4-1BB) costimulation of CD8+ T cells is more potent when provided in cis than in trans with respect to CD3-TCR stimulation

Otano, Itziar (författare)
University of Navarra,12 de Octubre University Hospital,Spanish National Cancer Research Center (CNIO),Spanish Center for Biomedical Research Network in Oncology (CIBERONC)
Azpilikueta, Arantza (författare)
University of Navarra,Health Research Institute of Navarra (IDISNA),Spanish Center for Biomedical Research Network in Oncology (CIBERONC)
Glez-Vaz, Javier (författare)
Health Research Institute of Navarra (IDISNA),University of Navarra,Spanish Center for Biomedical Research Network in Oncology (CIBERONC)
visa fler...
Alvarez, Maite (författare)
University of Navarra,Health Research Institute of Navarra (IDISNA),Spanish Center for Biomedical Research Network in Oncology (CIBERONC)
Medina-Echeverz, José (författare)
Bavarian Nordic GmbH
Cortés-Domínguez, Ivan (författare)
Health Research Institute of Navarra (IDISNA),University of Navarra
Ortiz-de-Solorzano, Carlos (författare)
Health Research Institute of Navarra (IDISNA),University of Navarra,Spanish Center for Biomedical Research Network in Oncology (CIBERONC)
Ellmark, Peter (författare)
Lund University,Lunds universitet,Institutionen för immunteknologi,Institutioner vid LTH,Lunds Tekniska Högskola,Department of Immunotechnology,Departments at LTH,Faculty of Engineering, LTH,Alligator Biosciences AB
Fritzell, Sara (författare)
Alligator Biosciences AB
Hernandez-Hoyos, Gabriela (författare)
Aptevo Therapeutics
Nelson, Michelle Hase (författare)
Aptevo Therapeutics
Ochoa, María Carmen (författare)
Health Research Institute of Navarra (IDISNA),Spanish Center for Biomedical Research Network in Oncology (CIBERONC),University of Navarra,University Clinic of Navarra
Bolaños, Elixabet (författare)
Health Research Institute of Navarra (IDISNA),University Clinic of Navarra,Spanish Center for Biomedical Research Network in Oncology (CIBERONC)
Cuculescu, Doina (författare)
Health Research Institute of Navarra (IDISNA),University of Navarra,Spanish Center for Biomedical Research Network in Oncology (CIBERONC)
Jaúregui, Patricia (författare)
Spanish Center for Biomedical Research Network in Oncology (CIBERONC),Health Research Institute of Navarra (IDISNA)
Sanchez-Gregorio, Sandra (författare)
University Clinic of Navarra,University of Navarra,Health Research Institute of Navarra (IDISNA),Spanish Center for Biomedical Research Network in Oncology (CIBERONC)
Etxeberria, Iñaki (författare)
Spanish Center for Biomedical Research Network in Oncology (CIBERONC),University of Navarra,Health Research Institute of Navarra (IDISNA)
Rodriguez-Ruiz, María E. (författare)
University Clinic of Navarra,Spanish Center for Biomedical Research Network in Oncology (CIBERONC),University of Navarra,Health Research Institute of Navarra (IDISNA)
Sanmamed, Miguel F. (författare)
University Clinic of Navarra,Spanish Center for Biomedical Research Network in Oncology (CIBERONC),University of Navarra,Health Research Institute of Navarra (IDISNA)
Teijeira, Álvaro (författare)
University of Navarra,Health Research Institute of Navarra (IDISNA),Spanish Center for Biomedical Research Network in Oncology (CIBERONC),University Clinic of Navarra
Berraondo, Pedro (författare)
Health Research Institute of Navarra (IDISNA),University of Navarra,Spanish Center for Biomedical Research Network in Oncology (CIBERONC)
Melero, Ignacio (författare)
Spanish Center for Biomedical Research Network in Oncology (CIBERONC),12 de Octubre University Hospital,University Clinic of Navarra,Spanish National Cancer Research Center (CNIO),University of Navarra,Health Research Institute of Navarra (IDISNA)
visa färre...
 (creator_code:org_t)
2021-12-15
2021
Engelska.
Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 12:1
Relaterad länk:
http://dx.doi.org/10... (free)
visa fler...
https://www.nature.c...
https://lup.lub.lu.s...
https://doi.org/10.1...
visa färre...
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • CD137 (4-1BB; TNFSR9) is an activation-induced surface receptor that through costimulation effects provide antigen-primed T cells with augmented survival, proliferation and effector functions as well as metabolic advantages. These immunobiological mechanisms are being utilised for cancer immunotherapy with agonist CD137-binding and crosslinking-inducing agents that elicit CD137 intracellular signaling. In this study, side-by-side comparisons show that provision of CD137 costimulation in-cis with regard to the TCR-CD3-ligating cell is superior to that provided in-trans in terms of T cell activation, proliferation, survival, cytokine secretion and mitochondrial fitness in mouse and human. Cis ligation of CD137 relative to the TCR-CD3 complex results in more intense canonical and non-canonical NF-κB signaling and provides a more robust induction of cell cycle and DNA damage repair gene expression programs. Here we report that the superiority of cis versus trans CD137-costimulation is readily observed in vivo and is relevant for understanding the immunotherapeutic effects of CAR T cells and CD137 agonistic therapies currently undergoing clinical trials, which may provide costimulation either in cis or in trans.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)

Publikations- och innehållstyp

art (ämneskategori)
ref (ämneskategori)

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy