Water uptake and release from iodine-containing bone cement.

• Water uptake and release characteristics of PMMA cement containing the water-soluble contrast media iohexol or iodixanol have been investigated. The water uptake study revealed that iohexol had the highest uptake of water (3.7%) and that iodixanol had an uptake close to that of Palacos(R) R (2.3% and 1.9%). The curves obtained showed the materials to follow classic diffusion theory, with an initial linearity with respect to t(1/2) making it possible to calculate the diffusion coefficients. This showed iohexol to have the lowest diffusion coefficient, Palacos(R) R the highest, and iodixanol close to that of Palacos(R) R. The release study showed that more iohexol than iodixanol was released from the bone cement; the long-term release was above 25 mug/ml, for iohexol compared to slightly above 10 mug/mL for iodixanol. A muCT investigation showed that the risk of developing an observable radiolucent zone is negligible. (C) 2004 Wiley Periodicals, Inc.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Ortopedi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Orthopaedics (hsv//eng)

Nyckelord

water uptake

water

release

poly(methyl methacrylate)

absorption characteristics

Publikations- och innehållstyp

art (ämneskategori)

ref (ämneskategori)