Progression of retinopathy in insulin-treated type 2 diabetic patients.

• OBJECTIVE—To study the progression of retinopathy 3 years after initiation of insulin therapy. RESEARCH DESIGN AND METHODS—In a prospective, observational case-control study, 42 type 2 diabetic patients were examined at baseline and 1, 3, 6, 12, 24, and 36 months after change to insulin therapy. Retinopathy was graded based on fundus photographs using the Wisconsin scale; HbA1c and IGF-1 were measured. RESULTS—During the observation period of 3 years, 26 patients progressed in the retinopathy scale; 11 patients progressed at least three levels. After 3 years of insulin therapy, HbA1c and IGF-1 were significantly lower than at baseline. Progression of retinopathy greater than or equal to three levels was related to high IGF-1 levels. CONCLUSIONS—A relationship was found between high IGF-1 levels at 3 years and progression of retinopathy in type 2 diabetic patients.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)

Nyckelord

Treatment Outcome

Non-U.S. Gov't

Support

Prospective Studies

Middle Age

Non-Insulin-Dependent: physiopathology

Diabetic Retinopathy: physiopathology

Disease Progression

Logistic Models

Insulin: administration & dosage

Hypoglycemic Agents: administration & dosage

Human

Follow-Up Studies

Male

Female

Non-Insulin-Dependent: drug therapy

Diabetes Mellitus

Non-Insulin-Dependent: complications

Aged

Case-Control Studies

Publikations- och innehållstyp

art (ämneskategori)

ref (ämneskategori)