Sökning: id:"swepub:oai:lup.lub.lu.se:d42480f5-a52a-4d4a-b48a-039d951d25f1" >
Characterization of...
Characterization of male breast cancer : Results of the EORTC 10085/TBCRC/BIG/NABCG International Male Breast Cancer Program
-
- Cardoso, F. (författare)
- European Organisation for Research and Treatment of Cancer,Champalimaud Foundation
-
- Bartlett, J. M.S. (författare)
- University of Edinburgh,Ontario Institute for Cancer Research,Erasmus University Medical Center,Dutch Breast Cancer Research Group (BOOG),Memorial Sloan-Kettering Cancer Center
-
- Slaets, L. (författare)
- European Organisation for Research and Treatment of Cancer
-
visa fler...
-
- van Deurzen, C. H.M. (författare)
- Erasmus University Medical Center,Memorial Sloan-Kettering Cancer Center,Weill Cornell Medical College
-
- van Leeuwen-Stok, E. (författare)
- Dutch Breast Cancer Research Group (BOOG)
-
- Porter, P. (författare)
- University of Washington,Fred Hutchinson Cancer Research Center
-
- Linderholm, B. (författare)
- Karolinska Institutet,Lund University,Sahlgrenska University Hospital
-
- Hedenfalk, I. (författare)
- Lund University,Lunds universitet,Bröst- och ovarialcancer,Forskargrupper vid Lunds universitet,Bröst/ovarialcancer,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breast and Ovarian Cancer Genomics,Lund University Research Groups,Breast/ovarian cancer,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
-
- Schröder, C. (författare)
- University Medical Center Groningen,Dutch Breast Cancer Research Group (BOOG)
-
- Martens, J. (författare)
- Erasmus University Medical Center,Dutch Breast Cancer Research Group (BOOG)
-
- Bayani, J. (författare)
- Ontario Institute for Cancer Research
-
- van Asperen, C. (författare)
- Dutch Breast Cancer Research Group (BOOG),Leiden University Medical Centre
-
- Murray, M. (författare)
- Memorial Sloan-Kettering Cancer Center,St Wojciechs Hospital
-
- Hudis, C. (författare)
- Memorial Sloan-Kettering Cancer Center,Weill Cornell Medical College
-
- Middleton, L. (författare)
- University of Texas
-
- Vermeij, J. (författare)
- Ziekenhuis Netwerk Antwerpen (ZNA)
-
- Punie, K. (författare)
- University Hospitals Leuven
-
- Fraser, J. (författare)
- Beatson West of Scotland Cancer Centre
-
- Nowaczyk, M. (författare)
- St Wojciechs Hospital
-
- Rubio, I. T. (författare)
- Vall d'Hebron University Hospital
-
- Aebi, S. (författare)
- SAKK Coordinating Center
-
- Kelly, C. (författare)
- All Ireland Cooperative Oncology Research Group (ICORG),European Organisation for Research and Treatment of Cancer
-
- Ruddy, K. J. (författare)
- Mayo Clinic Minnesota
-
- Winer, E. (författare)
- Dana-Farber Cancer Institute
-
- Nilsson, C. (författare)
- Västmanland Hospital
-
- Dal Lago, L. (författare)
- Institut Jules Bordet
-
- Korde, L. (författare)
- University of Washington
-
- Benstead, K. (författare)
- Cheltenham General Hospital
-
- Bogler, O. (författare)
- University of Texas
-
- Goulioti, T. (författare)
- Breast International Group
-
- Peric, A. (författare)
- European Organisation for Research and Treatment of Cancer
-
- Litière, S. (författare)
- European Organisation for Research and Treatment of Cancer
-
- Aalders, K. C. (författare)
- European Organisation for Research and Treatment of Cancer
-
- Poncet, C. (författare)
- European Organisation for Research and Treatment of Cancer
-
- Tryfonidis, K. (författare)
- European Organisation for Research and Treatment of Cancer
-
- Giordano, S. H. (författare)
- University of Texas
-
visa färre...
-
(creator_code:org_t)
- Elsevier BV, 2018
- 2018
- Engelska.
-
Ingår i: Annals of Oncology. - : Elsevier BV. - 1569-8041 .- 0923-7534. ; 29:2, s. 405-417
- Relaterad länk:
-
http://dx.doi.org/10...
-
visa fler...
-
http://www.annalsofo...
-
https://lup.lub.lu.s...
-
https://doi.org/10.1...
-
http://kipublication...
-
visa färre...
Abstract
Ämnesord
Stäng
- Background: Male breast cancer (BC) is rare, managed by extrapolation from female BC. The International Male BC Program aims to better characterize and manage this disease. We report the results of part I, a retrospective joint analysis of cases diagnosed during a 20-year period. Methods: Patients with follow-up and tumor samples, treated between 1990 and 2010, in 93 centers/9 countries. Samples were centrally analyzed in three laboratories (the United Kingdom, the Netherlands and the United States). Results: Of 1822 patients enrolled, 1483 were analyzed; 63.5% were diagnosed between 2001 and 2010, 57 (5.1%) had metastatic disease (M1). Median age at diagnosis: 68.4 years. Of 1054 M0 cases, 56.2% were node-negative (N0) and 48.5% had T1 tumors; 4% had breast conserving surgery (BCS), 18% sentinel lymph-node biopsy; half received adjuvant radiotherapy; 29.8% (neo)adjuvant chemotherapy and 76.8% adjuvant endocrine therapy (ET), mostly tamoxifen (88.4%). Per central pathology, for M0 tumors: 84.8% ductal invasive carcinomas, 51.5% grade 2; 99.3% estrogen receptor (ER)-positive; 81.9% progesterone receptor (PR)-positive; 96.9% androgen receptor (AR)-positive [ER, PR or AR Allred score ≥ 3]; 61.1% Ki67 expression low (<14% positive cells); using immunohistochemistry (IHC) surrogates, 41.9% were Luminal-A-like, 48.6% Luminal-B-like/HER-2-negative, 8.7% HER-2-positive, 0.3% triple negative. Median follow-up: 8.2 years (0.0-23.8) for all, 7.2 years (0.0-23.2), for M0, 2.6 years (0.0-12.7) for M1 patients. A significant improvement over time was observed in age-corrected BC mortality. BC-specific-mortality was higher for men younger than 50 years. Better overall (OS) and recurrence-free survival (RFS) were observed for highly ER+(P=0.001), highly PR+(P=0.002), highly AR+ disease (P=0.019). There was no association between OS/RFS and HER-2 status, Ki67, IHC subtypes nor grade. Conclusions: Male BC is usually ER, PR and AR-positive, Luminal B-like/HER2-negative. Of note, 56% patients had T1 tumors but only 4% had BCS. ER was highly positive in > 90% of cases but only 77% received adjuvant ET. ER, PR and AR were associated with OS and RFS, whereas grade, Ki67 and IHC surrogates were not. Significant improvement in survival over time was observed.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- Clinical and biological characteristics
- Consortium
- Male breast cancer
- Retrospective analysis
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Cardoso, F.
-
Bartlett, J. M.S ...
-
Slaets, L.
-
van Deurzen, C. ...
-
van Leeuwen-Stok ...
-
Porter, P.
-
visa fler...
-
Linderholm, B.
-
Hedenfalk, I.
-
Schröder, C.
-
Martens, J.
-
Bayani, J.
-
van Asperen, C.
-
Murray, M.
-
Hudis, C.
-
Middleton, L.
-
Vermeij, J.
-
Punie, K.
-
Fraser, J.
-
Nowaczyk, M.
-
Rubio, I. T.
-
Aebi, S.
-
Kelly, C.
-
Ruddy, K. J.
-
Winer, E.
-
Nilsson, C.
-
Dal Lago, L.
-
Korde, L.
-
Benstead, K.
-
Bogler, O.
-
Goulioti, T.
-
Peric, A.
-
Litière, S.
-
Aalders, K. C.
-
Poncet, C.
-
Tryfonidis, K.
-
Giordano, S. H.
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Cancer och onkol ...
- Artiklar i publikationen
-
Annals of Oncolo ...
- Av lärosätet
-
Lunds universitet
-
Karolinska Institutet