Breastfeeding does not influence the development of inhibitors in haemophilia.

• Our aim was to test the hypothesis that breastfeeding may reduce development of inhibitors in male infants with haemophilia by inducing an oral immune tolerance to factor VIII. To achieve that goal, we performed a structured epidemiological survey comprising all males born with severe haemophilia A (in all 100 patients, 19 with inhibitors) or haemophilia B (in all 16 patients, six with inhibitors) in Sweden in 1980-99. Our results show no protective effect of breastfeeding.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Hematologi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Hematology (hsv//eng)

Nyckelord

Immune Tolerance

Hemophilia A: immunology

Hemophilia B: immunology

Human

Preschool

Factor VIII: metabolism

Infant

Newborn

Male

Sweden

Autoantibodies: blood

Blood Coagulation Factor Inhibitors: metabolism

Breast Feeding

Child

Publikations- och innehållstyp

art (ämneskategori)

ref (ämneskategori)