Sökning: id:"swepub:oai:lup.lub.lu.se:d56fb286-7c1a-4cc4-a92d-60ae2b2775bf" >
Selective neuroprot...
Selective neuroprotective effects of the S18Y polymorphic variant of UCH-L1 in the dopaminergic system
-
Xilouri, Maria (författare)
-
Kyratzi, Elli (författare)
-
Pitychoutis, Pothitos M. (författare)
-
visa fler...
-
Papadopoulou-Daifoti, Zoi (författare)
-
Perier, Celine (författare)
-
Vila, Miquel (författare)
-
Maniati, Matina (författare)
-
- Ulusoy, Ayse (författare)
- Lund University,Lunds universitet,Brain Repair and Imaging in Neural Systems (BRAINS),Forskargrupper vid Lunds universitet,Lund University Research Groups
-
- Kirik, Deniz (författare)
- Lund University,Lunds universitet,Brain Repair and Imaging in Neural Systems (BRAINS),Forskargrupper vid Lunds universitet,Lund University Research Groups
-
Park, David S. (författare)
-
Wada, Keiji (författare)
-
Stefanis, Leonidas (författare)
-
visa färre...
-
(creator_code:org_t)
- 2011-11-10
- 2012
- Engelska.
-
Ingår i: Human Molecular Genetics. - : Oxford University Press (OUP). - 0964-6906 .- 1460-2083. ; 21:4, s. 874-889
- Relaterad länk:
-
http://dx.doi.org/10...
-
visa fler...
-
https://academic.oup...
-
https://lup.lub.lu.s...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Genetic studies have implicated the neuronal ubiquitin C-terminal hydrolase (UCH) protein UCH-L1 in Parkinson's disease (PD) pathogenesis. Moreover, the function of UCH-L1 may be lost in the brains of PD and Alzheimer's disease patients. We have previously reported that the UCH-L1 polymorphic variant S18Y, potentially protective against PD in population studies, demonstrates specific antioxidant functions in cell culture. Albeit genetic, biochemical and neuropathological data support an association between UCH-L1, PD, synaptic degeneration and oxidative stress, the relationship between the dopaminergic system and UCH-L1 status remains obscure. In the current study, we have examined the dopaminergic system of mice lacking endogenous UCH-L1 protein (gracile axonal dystrophy mice). Our findings show that the lack of wild-type (WT) UCH-L1 does not influence to any significant degree the dopaminergic system at baseline or following injections of the neurotoxin methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Furthermore, using a novel intrastriatal adenoviral injection protocol, we have found that mouse nigral neurons retrogradely transduced with S18Y UCH-L1, but not the WT protein, are significantly protected against MPTP toxicity. Overall, these data provide evidence for an antioxidant and neuroprotective effect of the S18Y variant of UCH-L1, but not of the WT protein, in the dopaminergic system, and may have implications for the pathogenesis of PD or related neurodegenerative conditions, in which oxidative stress might play a role.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Xilouri, Maria
-
Kyratzi, Elli
-
Pitychoutis, Pot ...
-
Papadopoulou-Dai ...
-
Perier, Celine
-
Vila, Miquel
-
visa fler...
-
Maniati, Matina
-
Ulusoy, Ayse
-
Kirik, Deniz
-
Park, David S.
-
Wada, Keiji
-
Stefanis, Leonid ...
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Medicinska och f ...
-
och Medicinsk geneti ...
- Artiklar i publikationen
-
Human Molecular ...
- Av lärosätet
-
Lunds universitet