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Detecting potential...
Detecting potential outliers in longitudinal data with time-dependent covariates
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- Mramba, Lazarus K. (författare)
- University of South Florida
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- Liu, Xiang (författare)
- University of South Florida
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- Lynch, Kristian F. (författare)
- University of South Florida
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- Yang, Jimin (författare)
- University of South Florida
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- Aronsson, Carin Andrén (författare)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups,Skåne University Hospital
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- Hummel, Sandra (författare)
- Klinikum rechts der Isar
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- Norris, Jill M. (författare)
- Colorado School of Public Health
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- Virtanen, Suvi M. (författare)
- Finnish National Institute for Health and Welfare,Tampere University Hospital,University of Tampere
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- Hakola, Leena (författare)
- University of Tampere,Tampere University Hospital
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- Uusitalo, Ulla M. (författare)
- University of South Florida
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- Krischer, Jeffrey P. (författare)
- University of South Florida
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(creator_code:org_t)
- Engelska.
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Ingår i: European Journal of Clinical Nutrition. - 0954-3007.
- Relaterad länk:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background: Outliers can influence regression model parameters and change the direction of the estimated effect, over-estimating or under-estimating the strength of the association between a response variable and an exposure of interest. Identifying visit-level outliers from longitudinal data with continuous time-dependent covariates is important when the distribution of such variable is highly skewed. Objectives: The primary objective was to identify potential outliers at follow-up visits using interquartile range (IQR) statistic and assess their influence on estimated Cox regression parameters. Methods: Study was motivated by a large TEDDY dietary longitudinal and time-to-event data with a continuous time-varying vitamin B12 intake as the exposure of interest and development of Islet Autoimmunity (IA) as the response variable. An IQR algorithm was applied to the TEDDY dataset to detect potential outliers at each visit. To assess the impact of detected outliers, data were analyzed using the extended time-dependent Cox model with robust sandwich estimator. Partial residual diagnostic plots were examined for highly influential outliers. Results: Extreme vitamin B12 observations that were cases of IA had a stronger influence on the Cox regression model than non-cases. Identified outliers changed the direction of hazard ratios, standard errors, or the strength of association with the risk of developing IA. Conclusion: At the exploratory data analysis stage, the IQR algorithm can be used as a data quality control tool to identify potential outliers at the visit level, which can be further investigated.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
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- Av författaren/redakt...
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Mramba, Lazarus ...
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Liu, Xiang
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Lynch, Kristian ...
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Yang, Jimin
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Aronsson, Carin ...
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Hummel, Sandra
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visa fler...
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Norris, Jill M.
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Virtanen, Suvi M ...
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Hakola, Leena
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Uusitalo, Ulla M ...
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Krischer, Jeffre ...
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Endokrinologi oc ...
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European Journal ...
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Lunds universitet