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The rs7903146 varia...
The rs7903146 variant in the tcf7l2 gene increases the risk of prediabetes/type 2 diabetes in obese adolescents by impairing b-cell function and hepatic insulin sensitivity
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- Cropano, Catrina (författare)
- Yale University
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- Santoro, Nicola (författare)
- Yale University
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- Groop, Leif (författare)
- Lund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups
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- Man, Chiara Dalla (författare)
- University of Padova
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- Cobelli, Claudio (författare)
- University of Padova
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- Galderisi, Alfonso (författare)
- Yale University
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- Kursawe, Romy (författare)
- The Jackson Laboratory
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- Pierpont, Bridget (författare)
- Yale University
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- Goffredo, Martina (författare)
- Yale University
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- Caprio, Sonia (författare)
- Yale University
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(creator_code:org_t)
- 2017-06-13
- 2017
- Engelska 8 s.
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Ingår i: Diabetes Care. - : American Diabetes Association. - 0149-5992 .- 1935-5548. ; 40:8, s. 1082-1089
- Relaterad länk:
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http://dx.doi.org/10...
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https://care.diabete...
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https://lup.lub.lu.s...
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https://doi.org/10.2...
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Abstract
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- OBJECTIVE In this study, we aimed to explore the mechanism by which TCF7L2 rs7903146 risk allele confers susceptibility to impaired glucose tolerance (IGT) or type 2 diabetes (T2D) in obese adolescents. RESEARCH DESIGN AND METHODS The rs7903146 variant in the TCF7L2 gene was genotyped in a multiethnic cohort of 955 youths. All subjects underwent an oral glucose tolerance test with the use of the Oral Minimal Model to assess insulin secretion, and 33 subjects underwent a hyperinsulinemic-euglycemic clamp. In 307 subjects, a follow-up oral glucose tolerance test was repeated after 3.11 6 2.36 years. RESULTS The TCF7L2 rs7903146 risk allele was associated with higher 2-h glucose levels in Caucasians (P = 0.006) and African Americans (P = 0.009), and a trendwas seen also in Hispanics (P = 0.072). Also, the T allele was associated with decreased b-cell responsivity and IGT (P < 0.05). Suppression of endogenous hepatic glucose productionwas lower in subjects with the risk variant (P = 0.006). Finally, the odds of showing IGT/T2D at follow-up were higher in subjects carrying the minor allele (odds ratio 2.224; 95% CI 1.370-3.612; P = 0.0012). CONCLUSIONS The rs7903146 variant in the TCF7L2 gene increases the risk of IGT/T2D in obese adolescents by impairing b-cell function, and hepatic insulin sensitivity predicts the development of IGT/T2D over time.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
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Till lärosätets databas
- Av författaren/redakt...
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Cropano, Catrina
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Santoro, Nicola
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Groop, Leif
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Man, Chiara Dall ...
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Cobelli, Claudio
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Galderisi, Alfon ...
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visa fler...
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Kursawe, Romy
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Pierpont, Bridge ...
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Goffredo, Martin ...
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Caprio, Sonia
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Endokrinologi oc ...
- Artiklar i publikationen
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Diabetes Care
- Av lärosätet
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Lunds universitet