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Secondary thalamic ...
Secondary thalamic lesions after ligation of the middle cerebral artery: an ultrastructural study
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Nordborg, C (författare)
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- Johansson, Barbro (författare)
- Lund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine
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(creator_code:org_t)
- Springer Science and Business Media LLC, 1995
- 1995
- Engelska.
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Ingår i: Acta Neuropathologica. - : Springer Science and Business Media LLC. - 1432-0533 .- 0001-6322. ; 91:1, s. 61-66
- Relaterad länk:
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http://dx.doi.org/10...
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Abstract
Ämnesord
Stäng
- Earlier light microscopic, immunocytochemical and morphometric investigations indicate that noxious substances transported with the vasogenic edema from hemispheric infarcts influence the character, timing and extent of the secondary thalamic lesions. The object of the present study was to analyze the ultrastructure of the secondary damage and the cytolytic nerve cell change which ensues in the thalamus within a week after the infarction. Adult spontaneously hypertensive rats (SHR) were studied either 7 days after permanent ligation of the right middle cerebral artery (MCA) (n = 4) or 7 days after a 2-h temporary occlusion of the MCA (n = 4). Light microscopy revealed damage in the ipsilateral thalamic nuclei and the electron microscopic analysis showed that the cytolytic nerve cell degeneration was somatodendritic. Central chromatolysis was not observed. Somatodendritic nerve cell degeneration, as found in the secondary thalamic lesions in the present study, has been described in excitotoxic brain damage as well as in chronic, edematous lesions in stroke-prone spontaneously hypertensive rats. The possibility that the cytolytic thalamic nerve cell lesion is influenced by excitatory, noxious substances spreading with the edema fluid from the infarct has, thus, to be considered.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Nyckelord
- Brain infarct
- Temporary arterial occlusion
- Permanent arterial occlusion
- Vasogenic edema
- Thalamus
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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