Infectious Agents, the Contact System, and Innate Immunity

• The early host response to an infection is dependent on an efficient innate immune system. The human contact system once activated at a bacterial surface results in the induction of proinflammatory reactions and the release of antimicrobial peptides, However, under severe conditions its systemic activation A may evoke the generation of pathologic levels of kinins and a consumption of contact factors, which can both contribute to the progression of the disease and cause life-threatening complications. The present review aims to give an update on the role of the contact system in infectious diseases. (C) 2008 S. Karger GmbH, Freiburg i.Br.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Infektionsmedicin (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Infectious Medicine (hsv//eng)

Nyckelord

Contact system

Coagulation

Infectious diseases

Inflammation

immunity

Innate

Publikations- och innehållstyp

kon (ämneskategori)

ref (ämneskategori)