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Exploring the micro...
Exploring the microbial landscape uncovering the pathogens associated with community-acquired pneumonia in hospitalized patients
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- Hansen, Karin (författare)
- Lund University,Lunds universitet,Infektionssjukdomar,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Institutionen för translationell medicin,Klinisk mikrobiologi, Malmö,Forskargrupper vid Lunds universitet,Infectious Diseases,Department of Clinical Sciences, Malmö,Faculty of Medicine,Department of Translational Medicine,Clinical Microbiology, Malmö,Lund University Research Groups
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- Yamba Yamba, Linda (författare)
- Lund University,Lunds universitet,Institutionen för translationell medicin,Medicinska fakulteten,Klinisk mikrobiologi, Malmö,Forskargrupper vid Lunds universitet,Department of Translational Medicine,Faculty of Medicine,Clinical Microbiology, Malmö,Lund University Research Groups
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- Wasserstrom, Lisa (författare)
- Lund University,Lunds universitet,Institutionen för laboratoriemedicin,Medicinska fakulteten,Institutionen för translationell medicin,Klinisk mikrobiologi, Malmö,Forskargrupper vid Lunds universitet,Klinisk infektionsmedicin,Department of Laboratory Medicine,Faculty of Medicine,Department of Translational Medicine,Clinical Microbiology, Malmö,Lund University Research Groups,Clinical infection medicine
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visa fler...
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- Rünow, Elisabeth (författare)
- Lund University,Lunds universitet,Infektionssjukdomar,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Institutionen för translationell medicin,Klinisk mikrobiologi, Malmö,Forskargrupper vid Lunds universitet,Infectious Diseases,Department of Clinical Sciences, Malmö,Faculty of Medicine,Department of Translational Medicine,Clinical Microbiology, Malmö,Lund University Research Groups
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- Göransson, Tommy (författare)
- Lund University
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- Nilsson, Anna (författare)
- Lund University,Lunds universitet,Infektionssjukdomar,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Institutionen för translationell medicin,Infectious Diseases,Department of Clinical Sciences, Malmö,Faculty of Medicine,Department of Translational Medicine
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- Ahl, Jonas (författare)
- Lund University,Lunds universitet,Infektionssjukdomar,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Institutionen för translationell medicin,Klinisk mikrobiologi, Malmö,Forskargrupper vid Lunds universitet,Infectious Diseases,Department of Clinical Sciences, Malmö,Faculty of Medicine,Department of Translational Medicine,Clinical Microbiology, Malmö,Lund University Research Groups
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- Riesbeck, Kristian (författare)
- Lund University,Lunds universitet,Institutionen för laboratoriemedicin,Medicinska fakulteten,Institutionen för translationell medicin,Klinisk mikrobiologi, Malmö,Forskargrupper vid Lunds universitet,Klinisk infektionsmedicin,Department of Laboratory Medicine,Faculty of Medicine,Department of Translational Medicine,Clinical Microbiology, Malmö,Lund University Research Groups,Clinical infection medicine
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(creator_code:org_t)
- 2023
- 2023
- Engelska 9 s.
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Ingår i: Frontiers in Public Health. - 2296-2565. ; 11
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://lup.lub.lu.s...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- OBJECTIVES: This study aimed to investigate the etiology, clinical features, and outcomes of community-acquired pneumonia (CAP) in adults. Understanding the causative pathogens is essential for effective treatment and prevention.DESIGN: Between 2016-2018, 518 hospitalized adults with CAP and 241 controls without symptoms were prospectively enrolled. Urine samples were collected for pneumococcal urinary antigen tests and nasopharyngeal swabs for viral and bacterial analysis, combined with routine diagnostic care.RESULTS: Among the included CAP patients, Streptococcus pneumoniae was the most common pathogen, detected in 28% of patients, followed by Haemophilus influenzae in 16%. Viruses were identified in 28%, and concurrent viruses and bacteria were detected in 15%. There was no difference in mortality, length of stay, or symptoms at hospitalization when comparing patients with bacterial, viral, or mixed etiologies. Among the control subjects without respiratory symptoms, S. pneumoniae, H. influenzae, or Moraxella catarrhalis were detected in 5-7%, and viruses in 7%. CONCLUSION: Streptococcus pneumoniae emerged as the predominant cause of CAP, followed closely by viruses and H. influenzae. Intriguingly, symptoms and outcome were similar regardless of etiology. These findings highlight the complexity of this respiratory infection and emphasize the importance of comprehensive diagnostic and treatment strategies. Clinical Trial Registration: ClinicalTrials.gov, identifier [NCT03606135].
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
Nyckelord
- Adult
- Humans
- Bacteria
- Community-Acquired Infections/epidemiology
- Hospitalization
- Pneumonia, Bacterial/epidemiology
- Respiratory Tract Infections
- Streptococcus pneumoniae
- Virus
- Haemophilus influenzae
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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