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Streptolysin O indu...
Streptolysin O induces the ubiquitination and degradation of pro-IL-1β
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- Hancz, Dóra (författare)
- Lund University,Lunds universitet,Värd-patogeninteraktioner,Forskargrupper vid Lunds universitet,Host-Pathogen Interactions,Lund University Research Groups
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- Westerlund, Elsa (författare)
- Lund University,Lunds universitet,Värd-patogeninteraktioner,Forskargrupper vid Lunds universitet,Host-Pathogen Interactions,Lund University Research Groups
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- Valfridsson, Christine (författare)
- Lund University,Lunds universitet,Infektionsimmunologi,Forskargrupper vid Lunds universitet,Värd-patogeninteraktioner,Infectious Immunology,Lund University Research Groups,Host-Pathogen Interactions
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- Aemero, Getachew Melkamu (författare)
- Lund University,Lunds universitet,Virusrekognition,Forskargrupper vid Lunds universitet,Virus Recognition,Lund University Research Groups
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- Bastiat-Sempe, Benedicte (författare)
- Boston Children's Hospital
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- Orning, Pontus (författare)
- Norwegian University of Science and Technology
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- Lien, Egil (författare)
- Norwegian University of Science and Technology
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- Wessels, Michael R. (författare)
- Boston Children's Hospital
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- Persson, Jenny J. (författare)
- Lund University,Lunds universitet,Värd-patogeninteraktioner,Forskargrupper vid Lunds universitet,Host-Pathogen Interactions,Lund University Research Groups
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(creator_code:org_t)
- 2019-03-19
- 2019
- Engelska.
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Ingår i: Journal of Innate Immunity. - : S. Karger AG. - 1662-811X .- 1662-8128. ; 11:6, s. 457-468
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://www.karger.c...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Group A Streptococcus (GAS) is a common and versatile human pathogen causing a variety of diseases. One of the many virulence factors of GAS is the secreted pore-forming cytotoxin streptolysin O (SLO), which has been ascribed multiple properties, including inflammasome activation leading to release of the potent inflammatory cytokine IL-1β from infected macrophages. IL-1β is synthesized as an inactive pro-form, which is activated intracellularly through proteolytic cleavage. Here, we use a macrophage infection model to show that SLO specifically induces ubiquitination and degradation of pro-IL-1β. Ubiquitination was dependent on SLO being released from the infecting bacterium, and pore formation by SLO was required but not sufficient for the induction of ubiquitination. Our data provide evidence for a novel SLO-mediated mechanism of immune regulation, emphasizing the importance of this pore-forming toxin in bacterial virulence and pathogenesis.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
Nyckelord
- Group A Streptococcus
- Streptolysin O
- Ubiquitin, IL-1β
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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