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Oral prednisone sup...
Oral prednisone suppresses allergic but not irritant patch test reactions in individuals hypersensitive to nickel
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- Anveden, I (författare)
- Karolinska Institutet
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- Lindberg, M (författare)
- Karolinska Institutet
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Andersen, KE (författare)
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- Bruze, Magnus (författare)
- Lund University,Lunds universitet,Yrkes- och miljödermatologi,Forskargrupper vid Lunds universitet,Occupational and Environmental Dermatology,Lund University Research Groups
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- Isaksson, Marléne (författare)
- Lund University,Lunds universitet,Yrkes- och miljödermatologi,Forskargrupper vid Lunds universitet,Occupational and Environmental Dermatology,Lund University Research Groups
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- Liden, C (författare)
- Karolinska Institutet
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Sommerlund, M (författare)
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Wahlberg, JE (författare)
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Wilkinson, JD (författare)
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Willis, CM (författare)
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(creator_code:org_t)
- Wiley, 2004
- 2004
- Engelska.
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Ingår i: Contact Dermatitis. - : Wiley. - 0105-1873 .- 1600-0536. ; 50:5, s. 298-303
- Relaterad länk:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- A multicentre, randomized, double-blind, crossover study was designed to investigate the effects of prednisone on allergic and irritant patch test reactions. 24 subjects with known allergy to nickel were recruited and patch tested with a nickel sulfate dilution series in aqueous solution, 5% nickel sulfate in petrolatum and 2 dilution series of the irritants nonanoic acid and sodium lauryl sulfate. The subjects were tested x2, both during treatment with prednisone 20 mg oral daily and during placebo treatment. The total number of positive nickel patch test reactions decreased significantly in patients during prednisone treatment. The threshold concentration to elicit a patch test reaction increased and the overall degree of reactivity to nickel sulfate shifted towards weaker reactions. The effect of prednisone treatment on the response to irritants was divergent with both increased and decreased numbers of reactions, although there were no statistically significant differences compared with placebo. It is concluded that oral treatment with prednisone suppresses patch test reactivity to nickel, but not to the irritants tested.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Dermatologi och venereologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Dermatology and Venereal Diseases (hsv//eng)
Nyckelord
- sodium lauryl sulfate
- prednisone
- placebo
- patch test reactivity
- nonanoic acid
- nickel
- corticosteroids
- suppression
- allergic contact dermatitis
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Anveden, I
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Lindberg, M
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Andersen, KE
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Bruze, Magnus
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Isaksson, Marlén ...
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Liden, C
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visa fler...
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Sommerlund, M
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Wahlberg, JE
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Wilkinson, JD
-
Willis, CM
-
visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Dermatologi och ...
- Artiklar i publikationen
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Contact Dermatit ...
- Av lärosätet
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Lunds universitet
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Karolinska Institutet