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A short history of ...
A short history of chromosome rearrangements and gene fusions in cancer
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- Mitelman, Felix (författare)
- Lund University,Lunds universitet,Avdelningen för klinisk genetik,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Genetics,Department of Laboratory Medicine,Faculty of Medicine
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Rowley, J D (redaktör/utgivare)
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Le Beau, M M (redaktör/utgivare)
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Rabbitts, T H (redaktör/utgivare)
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(creator_code:org_t)
- Cham : Springer International Publishing, 2015
- 2015
- Engelska 9 s.
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Ingår i: Chromosomal Translocations and Genome Rearrangements in Cancer. - Cham : Springer International Publishing. - 9783319199825 - 9783319199832 ; , s. 3-11
- Relaterad länk:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- The molecular characterization of recurrent chromosome aberrations in the early 1980s laid the foundation for gene fusion detection in cancer. This approach remained the unrivalled method to identify fusion genes for a quarter of a century and led to the detection of more than 700 neoplasia-associated fusion genes. The advancement of deep sequencing in the mid-2000s revolutionized the search for cytogenetically undetectable fusions, and such studies have dramatically changed the gene fusion landscape. A myriad of new gene fusions-more than 1,300-the great majority involving previously unsuspected genes, have been identified by sequencing-based analyses during the past 10 years.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
Nyckelord
- Chromosome aberrations
- Cytogenetics
- Gene fusions
- Karyotype
- Oncogenes
Publikations- och innehållstyp
- kap (ämneskategori)
- ref (ämneskategori)
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