Sökning: id:"swepub:oai:lup.lub.lu.se:ed3d7690-8fe7-4ecd-80cc-d62014735b5a" >
Age at first birth ...
Age at first birth and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers.
-
Kotsopoulos, J (författare)
-
Lubinski, J (författare)
-
Lynch, HT (författare)
-
visa fler...
-
Klijn J, Ghadirian, P (författare)
-
Neuhausen, SL (författare)
-
Kim-Sing, C (författare)
-
Foulkes, WD (författare)
-
Moller, P (författare)
-
Isaacs, C (författare)
-
Domchek, S (författare)
-
Randall, S (författare)
-
Offit, K (författare)
-
Tung, N (författare)
-
Ainsworth, P (författare)
-
Gershoni-Baruch, R (författare)
-
Eisen, A (författare)
-
- Daly, Mark (författare)
- Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups
-
Karlan, B (författare)
-
Saal, HM (författare)
-
Couch, F (författare)
-
Pasini, Barbara (författare)
-
- Olsson, Håkan (författare)
- Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Lunds Melanomstudiegrupp,Forskargrupper vid Lunds universitet,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund Melanoma Study Group,Lund University Research Groups,Skåne University Hospital
-
visa färre...
-
(creator_code:org_t)
-
- 2007-01-24
- 2007
- Engelska.
-
Ingår i: Breast Cancer Research and Treatment. - : Springer Science and Business Media LLC. - 1573-7217 .- 0167-6806. ; 105:2, s. 221-228
- Relaterad länk:
-
http://dx.doi.org/10...
-
visa fler...
-
https://lup.lub.lu.s...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- An early age at first full-term birth is associated with a reduction in the subsequent development of breast cancer among women in the general population. A similar effect has not yet been reported among women who carry an inherited BRCA1 or BRCA2 mutation. We conducted a matched case–control study on 1816 pairs of women with a BRCA1 (n = 1405) or BRCA2 (n = 411) mutation in an attempt to elucidate the relationship between age at first full-term pregnancy and the risk of developing breast cancer. Information about the age at first childbirth and other pregnancy-related variables was derived from a questionnaire administered to women during the course of genetic counselling. There was no difference in the mean age at first full-term birth in the cases and controls (24.9 years vs. 24.8 years; P = 0.81, respectively). Compared to women whose first child was born at or before 18 years of age, a later age at first full-term birth did not influence the risk of developing breast cancer (OR = 1.00 per year; 95% CI 0.98–1.03; P-trend = 0.67). Stratification by mutation status did not affect the results. These findings suggest that an early first full-term birth does not confer protection against breast cancer in BRCA mutation carriers. Nonetheless, BRCA mutation carriers opting for a prophylactic oophorectomy as a breast and/or ovarian cancer risk-reducing strategy should complete childbearing prior to age 40 when this prevention modality is most effective.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Nyckelord
- Case–control study
- Breast cancer
- BRCA2
- Age at first birth
- BRCA1
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Kotsopoulos, J
-
Lubinski, J
-
Lynch, HT
-
Klijn J, Ghadiri ...
-
Neuhausen, SL
-
Kim-Sing, C
-
visa fler...
-
Foulkes, WD
-
Moller, P
-
Isaacs, C
-
Domchek, S
-
Randall, S
-
Offit, K
-
Tung, N
-
Ainsworth, P
-
Gershoni-Baruch, ...
-
Eisen, A
-
Daly, Mark
-
Karlan, B
-
Saal, HM
-
Couch, F
-
Pasini, Barbara
-
Olsson, Håkan
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
- Artiklar i publikationen
-
Breast Cancer Re ...
- Av lärosätet
-
Lunds universitet