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Adipocyte lipases a...
Adipocyte lipases and defect of lipolysis in human obesity
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Langin, D (författare)
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- Dicker, A (författare)
- Karolinska Institutet
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Tavernier, G (författare)
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- Hoffstedt, J (författare)
- Karolinska Institutet
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Mairal, A (författare)
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- Ryden, M (författare)
- Karolinska Institutet
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Arner, E (författare)
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Sicard, A (författare)
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Jenkins, C M (författare)
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Viguerie, N (författare)
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van Harmelen, V (författare)
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Gross, R W (författare)
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- Holm, Cecilia (författare)
- Lund University,Lunds universitet,Molekylär endokrinologi,Forskargrupper vid Lunds universitet,Molecular Endocrinology,Lund University Research Groups
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- Arner, P (författare)
- Karolinska Institutet
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(creator_code:org_t)
- American Diabetes Association, 2005
- 2005
- Engelska.
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Ingår i: Diabetes. - : American Diabetes Association. - 1939-327X .- 0012-1797. ; 54:11, s. 3190-3197
- Relaterad länk:
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http://diabetes.diab... (free)
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http://diabetes.diab...
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https://lup.lub.lu.s...
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http://kipublication...
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https://doi.org/10.2...
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Abstract
Ämnesord
Stäng
- The mobilization of fat stored in adipose tissue is mediated by hormone-sensitive lipase (HSL) and the recently characterized adipose triglyceride lipase (ATGL), yet their relative importance in lipolysis is unknown. We show that a novel potent inhibitor of HSL does not inhibit other lipases. The compound counteracted catecholamine-stimulated lipolysis in mouse adipocytes and had no effect on residual triglyceride hydrolysis and lipolysis in HSL-null mice. In human adipocytes, catecholamine- and natriuretic peptide-induced lipolysis were completely blunted by the HSL inhibitor. When fat cells were not stimulated, glycerol but not fatty acid release was inhibited. HSL and ATGL mRNA levels increased concomitantly during adipocyte differentiation. Abundance of the two transcripts in human adipose tissue was highly correlated in habitual dietary conditions and during a hypocaloric diet, suggesting common regulatory mechanisms for the two genes. Comparison of obese and nonobese subjects showed that obesity was associated with a decrease in catecholamine-induced lipolysis and HSL expression in mature fat cells and in differentiated preadipocytes. In conclusion, HSL is the major lipase for catecholamine- and natriuretic peptide-stimulated lipolysis, whereas ATGL mediates the hydrolysis of triglycerides during basal lipolysis. Decreased catecholamine-induced lipolysis and low HSL expression constitute a possibly primary defect in obesity.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
Hitta via bibliotek
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Diabetes
(Sök värdpublikationen i LIBRIS)
Till lärosätets databas
- Av författaren/redakt...
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Langin, D
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Dicker, A
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Tavernier, G
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Hoffstedt, J
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Mairal, A
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Ryden, M
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visa fler...
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Arner, E
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Sicard, A
-
Jenkins, C M
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Viguerie, N
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van Harmelen, V
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Gross, R W
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Holm, Cecilia
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Arner, P
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Endokrinologi oc ...
- Artiklar i publikationen
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Diabetes
- Av lärosätet
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Lunds universitet
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Karolinska Institutet