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Plasma tumour necro...
Plasma tumour necrosis factor-alpha and early carotid atherosclerosis in healthy middle-aged men
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- Skoog, T (författare)
- Karolinska Institutet
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Dichtl, W (författare)
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Boquist, S (författare)
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visa fler...
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- Skoglund-Andersson, C (författare)
- Karolinska Institutet
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Karpe, F (författare)
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Tang, R (författare)
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Bond, MG (författare)
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- de Faire, U (författare)
- Karolinska Institutet
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- Johansson, Jenny G (författare)
- Lund University,Lunds universitet,Molekylär neurogenetik,Forskargrupper vid Lunds universitet,Molecular Neurogenetics,Lund University Research Groups
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- Eriksson, P (författare)
- Karolinska Institutet
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- Hamsten, A (författare)
- Karolinska Institutet
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Nilsson, J (författare)
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(creator_code:org_t)
- Oxford University Press (OUP), 2002
- 2002
- Engelska.
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Ingår i: European Heart Journal. - : Oxford University Press (OUP). - 1522-9645 .- 0195-668X. ; 23:5, s. 376-383
- Relaterad länk:
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http://dx.doi.org/10...
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https://academic.oup...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Aims Tumour necrosis factor-alpha (TNF-alpha) is a proinflammatory cytokine, which is implicated in some metabolic disorders and may play a role in the development of cardiovascular disease. We examined whether plasma TNF-alpha is related to established cardiovascular risk indicators, plasma levels of soluble cellular adhesion molecules and carotid artery intima-media thickness determined by ultrasound examination in a population-based cohort of 96 healthy 50-year-old men. Methods and Results TNF-alpha and cellular adhesion molecules were measured with enzyme-linked immunosorbent assays. Plasma TNF-alpha concentration was associated with systolic and diastolic blood pressure, degrees of alimentary lipaemia, plasma very low density lipoprotein triglyceride, low density lipoprotein (LDL) cholesterol concentrations and peak LDL particle size. Two indices of insulin resistance as well as all soluble cellular adhesion molecules correlated positively with TNF-alpha. The plasma TNF-alpha concentration was associated with common carotid intima-media thickness in univariate analysis. In contrast, soluble E-selectin and postprandial triglycerides, but not TNF-alpha, were independent determinants of common carotid intima-media thickness. Conclusion The plasma TNF-alpha concentration is associated with degrees of early atherosclerosis and correlates with metabolic and cellular perturbations that are considered important for the vascular process.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- common carotid intima-media thickness
- atherosclerosis
- tumour necrosis
- intercellular adhesion molecule-1
- factor-alpha
- vascular adhesion
- molecule-1
- E-selectin
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Skoog, T
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Dichtl, W
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Boquist, S
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Skoglund-Anderss ...
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Karpe, F
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Tang, R
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visa fler...
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Bond, MG
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de Faire, U
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Johansson, Jenny ...
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Eriksson, P
-
Hamsten, A
-
Nilsson, J
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Kardiologi
- Artiklar i publikationen
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European Heart J ...
- Av lärosätet
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Lunds universitet
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Karolinska Institutet