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CenTauR : Toward a ...
CenTauR : Toward a universal scale and masks for standardizing tau imaging studies
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- Villemagne, Victor L. (författare)
- University of Pittsburgh,Austin Health
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- Leuzy, Antoine (författare)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,LU profilområde: Proaktivt åldrande,Lunds universitets profilområden,Clinical Memory Research,Lund University Research Groups,LU Profile Area: Proactive Ageing,Lund University Profile areas
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- Bohorquez, Sandra Sanabria (författare)
- Genentech, Inc
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Bullich, Santiago (författare)
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Shimada, Hitoshi (författare)
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- Rowe, Christopher C. (författare)
- Austin Health,University of Melbourne
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- Bourgeat, Pierrick (författare)
- Commonwealth Scientific and Industrial Research Organisation (CSIRO)
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- Lopresti, Brian (författare)
- University of Pittsburgh
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- Huang, Kun (författare)
- Austin Health
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- Krishnadas, Natasha (författare)
- Austin Health,The Florey Institute of Neuroscience and Mental Health
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- Fripp, Jurgen (författare)
- Commonwealth Scientific and Industrial Research Organisation (CSIRO)
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Takado, Yuhei (författare)
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- Gogola, Alexandra (författare)
- University of Pittsburgh
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- Minhas, Davneet (författare)
- University of Pittsburgh
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- Weimer, Robby (författare)
- Genentech, Inc
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Higuchi, Makoto (författare)
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Stephens, Andrew (författare)
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- Hansson, Oskar (författare)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,LU profilområde: Proaktivt åldrande,Lunds universitets profilområden,Clinical Memory Research,Lund University Research Groups,LU Profile Area: Proactive Ageing,Lund University Profile areas,Skåne University Hospital
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- Doré, Vincent (författare)
- Commonwealth Scientific and Industrial Research Organisation (CSIRO),Austin Health
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(creator_code:org_t)
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- 2023
- 2023
- Engelska.
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Ingår i: Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring. - 2352-8729. ; 15:3
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- INTRODUCTION: Recently, an increasing number of tau tracers have become available. There is a need to standardize quantitative tau measures across tracers, supporting a universal scale. We developed several cortical tau masks and applied them to generate a tau imaging universal scale. METHOD: One thousand forty-five participants underwent tau scans with either 18F-flortaucipir, 18F-MK6240, 18F-PI2620, 18F-PM-PBB3, 18F-GTP1, or 18F-RO948. The universal mask was generated from cognitively unimpaired amyloid beta (Aβ)− subjects and Alzheimer's disease (AD) patients with Aβ+. Four additional regional cortical masks were defined within the constraints of the universal mask. A universal scale, the CenTauRz, was constructed. RESULTS: None of the regions known to display off-target signal were included in the masks. The CenTauRz allows robust discrimination between low and high levels of tau deposits. DISCUSSION: We constructed several tau-specific cortical masks for the AD continuum and a universal standard scale designed to capture the location and degree of abnormality that can be applied across tracers and across centers. The masks are freely available at https://www.gaain.org/centaur-project.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
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- art (ämneskategori)
- ref (ämneskategori)
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- Av författaren/redakt...
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Villemagne, Vict ...
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Leuzy, Antoine
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Bohorquez, Sandr ...
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Bullich, Santiag ...
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Shimada, Hitoshi
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Rowe, Christophe ...
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Bourgeat, Pierri ...
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Lopresti, Brian
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Huang, Kun
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Krishnadas, Nata ...
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Fripp, Jurgen
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Takado, Yuhei
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Gogola, Alexandr ...
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Minhas, Davneet
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Weimer, Robby
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Higuchi, Makoto
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Stephens, Andrew
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Hansson, Oskar
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Doré, Vincent
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Neurologi
- Artiklar i publikationen
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Alzheimer's and ...
- Av lärosätet
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Lunds universitet