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A Consensus Molecul...
A Consensus Molecular Classification of Muscle-invasive Bladder Cancer
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- Kamoun, Aurélie (författare)
- Ligue Nationale Contre le Cancer
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- Reyniès, Aurélien de (författare)
- Ligue Nationale Contre le Cancer
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- Allory, Yves (författare)
- Curie Institute, Paris
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- Sjödahl, Gottfrid (författare)
- Lund University,Lunds universitet,Genomiska analyser av urinblåscancer,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Urothelial Cancer Genomics,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Skåne University Hospital
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- Gordon Robertson, A. (författare)
- British Columbia Cancer Agency
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- Seiler, Roland (författare)
- Bern University Hospital
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- Hoadley, Katherine A. (författare)
- University of North Carolina
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- Groeneveld, Clarice S. (författare)
- Federal University of Paraná,Curie Institute, Paris,Ligue Nationale Contre le Cancer
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- Al-Ahmadie, Hikmat (författare)
- Memorial Sloan-Kettering Cancer Center
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- Choi, Woonyoung (författare)
- Johns Hopkins University
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- Castro, Mauro A.A. (författare)
- Federal University of Paraná
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- Fontugne, Jacqueline (författare)
- Curie Institute, Paris
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- Eriksson, Pontus (författare)
- Lund University,Lunds universitet,Genomiska analyser av urinblåscancer,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Urothelial Cancer Genomics,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments
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- Mo, Qianxing (författare)
- H. Lee Moffitt Cancer Center & Research Institute
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- Kardos, Jordan (författare)
- University of North Carolina
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- Zlotta, Alexandre (författare)
- University of Toronto,Mount Sinai Hospital of University of Toronto
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- Hartmann, Arndt (författare)
- Friedrich-Alexander University Erlangen-Nürnberg
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- Dinney, Colin P. (författare)
- University of Texas
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- Bellmunt, Joaquim (författare)
- Harvard University
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- Powles, Thomas (författare)
- Queen Mary University,National Health Service Trust, NHS England
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- Malats, Núria (författare)
- Spanish National Cancer Research Center (CNIO)
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- Chan, Keith S. (författare)
- Cedars-Sinai Medical Center
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- Kim, William Y. (författare)
- University of North Carolina
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- McConkey, David J. (författare)
- Johns Hopkins University
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- Black, Peter C. (författare)
- University of British Columbia
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- Dyrskjøt, Lars (författare)
- Aarhus University Hospital
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- Höglund, Mattias (författare)
- Lund University,Lunds universitet,Genomiska analyser av urinblåscancer,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Urothelial Cancer Genomics,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments
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- Lerner, Seth P. (författare)
- Baylor College of Medicine
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- Real, Francisco X. (författare)
- Spanish National Cancer Research Center (CNIO)
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- Radvanyi, François (författare)
- Curie Institute, Paris
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- Liedberg, Fredrik (creator_code:cre_t)
- Lund University,Lunds universitet,Urologi - blåscancer, Malmö,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Urinblåsecancer,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Urology - urothelial cancer, Malmö,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Urothelial cancer,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital
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(creator_code:org_t)
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- Elsevier BV, 2020
- 2020
- Engelska 14 s.
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Ingår i: European Urology. - : Elsevier BV. - 0302-2838. ; 77:4, s. 420-433
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background: Muscle-invasive bladder cancer (MIBC) is a molecularly diverse disease with heterogeneous clinical outcomes. Several molecular classifications have been proposed, but the diversity of their subtype sets impedes their clinical application. Objective: To achieve an international consensus on MIBC molecular subtypes that reconciles the published classification schemes. Design, setting, and participants: We used 1750 MIBC transcriptomic profiles from 16 published datasets and two additional cohorts. Outcome measurements and statistical analysis: We performed a network-based analysis of six independent MIBC classification systems to identify a consensus set of molecular classes. Association with survival was assessed using multivariable Cox models. Results and limitations: We report the results of an international effort to reach a consensus on MIBC molecular subtypes. We identified a consensus set of six molecular classes: luminal papillary (24%), luminal nonspecified (8%), luminal unstable (15%), stroma-rich (15%), basal/squamous (35%), and neuroendocrine-like (3%). These consensus classes differ regarding underlying oncogenic mechanisms, infiltration by immune and stromal cells, and histological and clinical characteristics, including outcomes. We provide a single-sample classifier that assigns a consensus class label to a tumor sample's transcriptome. Limitations of the work are retrospective clinical data collection and a lack of complete information regarding patient treatment. Conclusions: This consensus system offers a robust framework that will enable testing and validation of predictive biomarkers in future prospective clinical trials. Patient summary: Bladder cancers are heterogeneous at the molecular level, and scientists have proposed several classifications into sets of molecular classes. While these classifications may be useful to stratify patients for prognosis or response to treatment, a consensus classification would facilitate the clinical use of molecular classes. Conducted by multidisciplinary expert teams in the field, this study proposes such a consensus and provides a tool for applying the consensus classification in the clinical setting.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- Consensus
- Molecular taxonomy
- Muscle-invasive bladder cancer
- Transcriptomic classifier
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Kamoun, Aurélie
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Reyniès, Aurélie ...
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Allory, Yves
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Sjödahl, Gottfri ...
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Gordon Robertson ...
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Seiler, Roland
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visa fler...
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Hoadley, Katheri ...
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Groeneveld, Clar ...
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Al-Ahmadie, Hikm ...
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Choi, Woonyoung
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Castro, Mauro A. ...
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Fontugne, Jacque ...
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Eriksson, Pontus
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Mo, Qianxing
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Kardos, Jordan
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Zlotta, Alexandr ...
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Hartmann, Arndt
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Dinney, Colin P.
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Bellmunt, Joaqui ...
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Powles, Thomas
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Malats, Núria
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Chan, Keith S.
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Kim, William Y.
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McConkey, David ...
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Black, Peter C.
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Dyrskjøt, Lars
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Höglund, Mattias
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Lerner, Seth P.
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Real, Francisco ...
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Radvanyi, Franço ...
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Liedberg, Fredri ...
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Medicinsk geneti ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
- Artiklar i publikationen
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European Urology
- Av lärosätet
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Lunds universitet