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Migraine associated...
Migraine associated with altitude : results from a population-based study in Nepal
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- Linde, M. (författare)
- St. Olav’s University Hospital,Norwegian University of Science and Technology
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- Edvinsson, L. (författare)
- Lund University,Lunds universitet,Medicin/akutsjukvård, Lund,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Experimentell kärlforskning,Forskargrupper vid Lunds universitet,Medicine, Lund,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Experimental Vascular Research,Lund University Research Groups
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- Manandhar, K. (författare)
- Norwegian University of Science and Technology,Kathmandu University Hospital
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- Risal, A. (författare)
- Norwegian University of Science and Technology,Kathmandu University Hospital
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- Steiner, Timothy J. (författare)
- Imperial College London,Norwegian University of Science and Technology
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St Olav’s University Hospital Norwegian University of Science and Technology (creator_code:org_t)
- 2017-05-29
- 2017
- Engelska 7 s.
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Ingår i: European Journal of Neurology. - : Wiley. - 1351-5101. ; 24:8, s. 1055-1061
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://onlinelibrar...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background and purpose: A 1988 pilot study in Peru suggested an association between migraine and chronic exposure to high altitude. This study provides epidemiological evidence corroborating this. Methods: In a cross-sectional nationwide population-based study, a representative sample of Nepali-speaking adults were recruited through stratified multistage cluster sampling. They were visited at home by trained interviewers using a culturally adapted questionnaire. The altitude of dwelling of each participant was recorded. Results: Of 2100 participants, over half [1100 (52.4%)] were resident above 1000 m and almost one quarter [470 (22.4%)] at ≥2000 m. Age- and gender-standardized migraine prevalence increased from 27.9% to 45.5% with altitude between 0 and 2499 m and thereafter decreased to 37.9% at ≥2500 m. The likelihood of having migraine was greater (odds ratio, 1.5–2.2; P ≤ 0.007) at all higher altitudes compared with <500 m. In addition, all symptom indices increased with altitude across the range <500 m to 2000–2499 m, i.e. median attack frequency from 1.3 to 3.0 days/month (P < 0.001), median duration from 9 to 24 h (P < 0.001) and pain intensity [the proportion reporting ‘bad pain’ (highest intensity)] from 35.5% to 56.9% (P = 0.011). Each of these showed a downward trend above 2500 m. Conclusions: Dwelling at high altitudes increases not only migraine prevalence but also the severity of its symptoms.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Nyckelord
- altitude
- epidemiology
- Global Campaign against Headache
- headache
- hypoxia
- migraine
- prevalence
- risk factors
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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