Sökning: id:"swepub:oai:lup.lub.lu.se:fb44e2b6-90e5-4f70-b2b1-3c41aa5183a7" >
The Effect of Low-D...
The Effect of Low-Dose Glucocorticoids Over Two Years on Weight and Blood Pressure in Rheumatoid Arthritis : Individual Patient Data From Five Randomized Trials
-
- Palmowski, Andriko (författare)
- Charité - University Medicine Berlin,Frederiksberg Hospital
-
- Nielsen, Sabrina M. (författare)
- Odense University Hospital,Frederiksberg Hospital
-
- Boyadzhieva, Zhivana (författare)
- Charité - University Medicine Berlin
-
visa fler...
-
- Hartman, Linda (författare)
- Vrije Universiteit Amsterdam
-
- Oldenkott, Judith (författare)
- Charité - University Medicine Berlin
-
- Svensson, Björn (författare)
- Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine
-
- Hafström, Ingiäld (författare)
- Karolinska Institutet,Karolinska University Hospital
-
Wassenberg, Siegfried (författare)
-
- Choy, Ernest (författare)
- Cardiff University
-
- Kirwan, John (författare)
- University of Bristol
-
- Christensen, Robin (författare)
- Frederiksberg Hospital,Odense University Hospital
-
- Boers, Maarten (författare)
- Vrije Universiteit Amsterdam
-
- Buttgereit, Frank (författare)
- Charité - University Medicine Berlin
-
visa färre...
-
(creator_code:org_t)
- 2023
- 2023
- Engelska 9 s.
-
Ingår i: Annals of Internal Medicine. - 0003-4819 .- 1539-3704. ; 176:9, s. 1181-1189
- Relaterad länk:
-
http://dx.doi.org/10...
-
visa fler...
-
https://lup.lub.lu.s...
-
https://doi.org/10.7...
-
http://kipublication...
-
visa färre...
Abstract
Ämnesord
Stäng
- Background: Weight gain and hypertension are well known adverse effects of treatment with high-dose glucocorticoids. Objective: To evaluate the effects of 2 years of low-dose glucocorticoid treatment in rheumatoid arthritis (RA). Design: Pooled analysis of 5 randomized controlled trials with 2-year interventions allowing concomitant treatment with disease-modifying antirheumatic drugs. Setting: 12 countries in Europe. Patients: Early and established RA. Intervention: Glucocorticoids at 7.5 mg or less prednisone equivalent per day. Measurements: Coprimary end points were differences in change from baseline in body weight and mean arterial pressure after 2 years in intention-to-treat analyses. Difference in the change of number of antihypertensive drugs after 2 years was a secondary end point. Subgroup and sensitivity analyses were done to assess the robustness of primary findings. Results: A total of 1112 participants were included (mean age, 61.4 years [SD, 14.5]; 68% women). Both groups gained weight in 2 years, but glucocorticoids led, on average, to 1.1 kg (95% CI, 0.4 to 1.8 kg; P < 0.001) more weight gain than the control treatment. Mean arterial pressure increased by about 2 mm Hg in both groups, with a between-group difference of -0.4 mm Hg (CI, -3.0 to 2.2 mm Hg; P = 0.187). These results were consistent in sensitivity and subgroup analyses. Most patients did not change the number of antihypertensive drugs, and there was no evidence of differences between groups. Limitation: Body composition was not assessed, and generalizability to non-European regions may be limited. Conclusion: This study provides robust evidence that low-dose glucocorticoids, received over 2 years for the treatment of RA, increase weight by about 1 kg but do not increase blood pressure.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Palmowski, Andri ...
-
Nielsen, Sabrina ...
-
Boyadzhieva, Zhi ...
-
Hartman, Linda
-
Oldenkott, Judit ...
-
Svensson, Björn
-
visa fler...
-
Hafström, Ingiäl ...
-
Wassenberg, Sieg ...
-
Choy, Ernest
-
Kirwan, John
-
Christensen, Rob ...
-
Boers, Maarten
-
Buttgereit, Fran ...
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Reumatologi och ...
- Artiklar i publikationen
-
Annals of Intern ...
- Av lärosätet
-
Lunds universitet
-
Karolinska Institutet