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Processes Underlyin...
Processes Underlying Glycemic Deterioration in Type 2 Diabetes : An IMI DIRECT Study
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- Bizzotto, Roberto (författare)
- Institute of Neuroscience, Università di Padova,CNR Inst Neurosci, Padua, Italy.
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- Jennison, Christopher (författare)
- University of Bath
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- Jones, Angus G. (författare)
- University of Exeter,Royal Devon and Exeter NHS Foundation Trust
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- Kurbasic, Azra (författare)
- Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups,Skåne University Hospital
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- Tura, Andrea (författare)
- Institute of Neuroscience, Università di Padova,University of Exeter,Royal Devon and Exeter NHS Foundation Trust
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- Kennedy, Gwen (författare)
- Ninewells Hospital and Medical School
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- Bell, Jimmy D. (författare)
- University of Westminster
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- Thomas, E. Louise (författare)
- University of Westminster
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- Frost, Gary (författare)
- Imperial College London
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- Eriksen, Rebeca (författare)
- Imperial College London
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- Koivula, Robert W. (författare)
- Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups,University of Oxford,Skåne University Hospital
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- Brage, Soren (författare)
- University of Cambridge
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- Kaye, Jane (författare)
- University of Oxford,University of Melbourne
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- Hattersley, Andrew T. (författare)
- University of Exeter,Royal Devon and Exeter NHS Foundation Trust
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- Heggie, Alison (författare)
- University of Newcastle upon Tyne
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- McEvoy, Donna (författare)
- Royal Victoria Infirmary
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- 't Hart, Leen M. (författare)
- Leiden University Medical Centre,Amsterdam UMC - Vrije Universiteit Amsterdam
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- Beulens, Joline W. (författare)
- Amsterdam UMC - Vrije Universiteit Amsterdam
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- Elders, Petra (författare)
- Amsterdam UMC - Vrije Universiteit Amsterdam
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- Musholt, Petra B. (författare)
- Sanofi-Aventis Deutschland GmbH
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- Ridderstråle, Martin (författare)
- Novo Nordisk A/S
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- Hansen, Tue H. (författare)
- University of Copenhagen
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- Allin, Kristine H. (författare)
- University of Copenhagen
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- Hansen, Torben (författare)
- University of Copenhagen
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- Vestergaard, Henrik (författare)
- Bornholms Hospital,University of Copenhagen
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- Lundgaard, Agnete T. (författare)
- University of Copenhagen,Technical University of Denmark
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- Thomsen, Henrik S. (författare)
- University of Copenhagen
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- De Masi, Federico (författare)
- Technical University of Denmark
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- Tsirigos, Konstantinos D. (författare)
- University of Copenhagen,Technical University of Denmark
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- Brunak, Søren (författare)
- University of Copenhagen,Technical University of Denmark
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- Viñuela, Ana (författare)
- University of Newcastle upon Tyne,University of Geneva
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- Mahajan, Anubha (författare)
- Wellcome Trust Centre for Human Genetics,University of Oxford
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- McDonald, Timothy J. (författare)
- University of Exeter,Royal Devon and Exeter NHS Foundation Trust
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- Kokkola, Tarja (författare)
- University of Eastern Finland
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- Forgie, Ian M. (författare)
- University of Dundee
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- Giordano, Giuseppe N. (författare)
- Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups,Skåne University Hospital
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- Pavo, Imre (författare)
- Eli Lilly Regional Operations G.m.b.H.
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- Ruetten, Hartmut (författare)
- Sanofi-Aventis Deutschland GmbH
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- Dermitzakis, Emmanouil (författare)
- University of Geneva
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- McCarthy, Mark I. (författare)
- Wellcome Trust Centre for Human Genetics,University of Oxford,Oxford University Hospital
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- Pedersen, Oluf (författare)
- University of Copenhagen
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- Schwenk, Jochen M. (författare)
- KTH,KTH Royal Institute of Technology,Affinitets-proteomik,Science for Life Laboratory, SciLifeLab
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- Adamski, Jerzy (författare)
- Technical University of Munich,Helmholtz Zentrum München,National University of Singapore
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- Franks, Paul W. (författare)
- Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups,Skåne University Hospital
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- Walker, Mark (författare)
- University of Newcastle upon Tyne
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- Pearson, Ewan R. (författare)
- University of Dundee
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- Mari, Andrea (författare)
- Institute of Neuroscience, Università di Padova,CNR Inst Neurosci, Padua, Italy.;Genentech Inc, San Francisco, CA USA.
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Institute of Neuroscience, Università di Padova CNR Inst Neurosci, Padua, Italy (creator_code:org_t)
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- 2020-12-15
- 2021
- Engelska 8 s.
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Ingår i: Diabetes Care. - : American Diabetes Association. - 1935-5548 .- 0149-5992. ; 44:2, s. 511-518
- Relaterad länk:
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http://dx.doi.org/10...
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https://diabetesjour...
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https://lup.lub.lu.s...
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https://doi.org/10.2...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- OBJECTIVE: We investigated the processes underlying glycemic deterioration in type 2 diabetes (T2D). RESEARCH DESIGN AND METHODS: A total of 732 recently diagnosed patients with T2D from the Innovative Medicines Initiative Diabetes Research on Patient Stratification (IMI DIRECT) study were extensively phenotyped over 3 years, including measures of insulin sensitivity (OGIS), β-cell glucose sensitivity (GS), and insulin clearance (CLIm) from mixed meal tests, liver enzymes, lipid profiles, and baseline regional fat from MRI. The associations between the longitudinal metabolic patterns and HbA1c deterioration, adjusted for changes in BMI and in diabetes medications, were assessed via stepwise multivariable linear and logistic regression. RESULTS: Faster HbA1c progression was independently associated with faster deterioration of OGIS and GS and increasing CLIm; visceral or liver fat, HDL-cholesterol, and triglycerides had further independent, though weaker, roles (R2 = 0.38). A subgroup of patients with a markedly higher progression rate (fast progressors) was clearly distinguishable considering these variables only (discrimination capacity from area under the receiver operating characteristic = 0.94). The proportion of fast progressors was reduced from 56% to 8-10% in subgroups in which only one trait among OGIS, GS, and CLIm was relatively stable (odds ratios 0.07-0.09). T2D polygenic risk score and baseline pancreatic fat, glucagon-like peptide 1, glucagon, diet, and physical activity did not show an independent role. CONCLUSIONS: Deteriorating insulin sensitivity and β-cell function, increasing insulin clearance, high visceral or liver fat, and worsening of the lipid profile are the crucial factors mediating glycemic deterioration of patients with T2D in the initial phase of the disease. Stabilization of a single trait among insulin sensitivity, β-cell function, and insulin clearance may be relevant to prevent progression.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
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Till lärosätets databas
- Av författaren/redakt...
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Bizzotto, Robert ...
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Jennison, Christ ...
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Jones, Angus G.
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Kurbasic, Azra
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Tura, Andrea
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Kennedy, Gwen
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visa fler...
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Bell, Jimmy D.
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Thomas, E. Louis ...
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Frost, Gary
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Eriksen, Rebeca
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Koivula, Robert ...
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Brage, Soren
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Kaye, Jane
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Hattersley, Andr ...
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Heggie, Alison
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McEvoy, Donna
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't Hart, Leen M.
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Beulens, Joline ...
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Elders, Petra
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Musholt, Petra B ...
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Ridderstråle, Ma ...
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Hansen, Tue H.
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Allin, Kristine ...
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Hansen, Torben
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Vestergaard, Hen ...
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Lundgaard, Agnet ...
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Thomsen, Henrik ...
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De Masi, Federic ...
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Tsirigos, Konsta ...
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Brunak, Søren
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Viñuela, Ana
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Mahajan, Anubha
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McDonald, Timoth ...
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Kokkola, Tarja
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Forgie, Ian M.
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Giordano, Giusep ...
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Pavo, Imre
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Ruetten, Hartmut
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Dermitzakis, Emm ...
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McCarthy, Mark I ...
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Pedersen, Oluf
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Schwenk, Jochen ...
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Adamski, Jerzy
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Franks, Paul W.
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Walker, Mark
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Pearson, Ewan R.
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Mari, Andrea
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Endokrinologi oc ...
- Artiklar i publikationen
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Diabetes Care
- Av lärosätet
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Lunds universitet
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Kungliga Tekniska Högskolan