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Pregnancy Outcomes ...
Pregnancy Outcomes in Women Screened for Tuberculosis Infection in Swedish Antenatal Care
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- Walles, John (author)
- Lund University,Lunds universitet,Klinisk infektionsmedicin,Forskargrupper vid Lunds universitet,Clinical infection medicine,Lund University Research Groups,Skåne University Hospital,Central Hospital Kristianstad,Lund Univ, Sweden; Cent Hosp Kristianstad, Sweden; Skane Univ Hosp, Sweden; Clin Infect Med, Sweden
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- Winqvist, Niclas (author)
- Region Skåne,Skane Reg Off Infect Dis Control & Prevent, Sweden
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- Hansson, Stefan R. (author)
- Lund University,Lunds universitet,Obstetrik och gynekologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Enheten för translationell obstetrisk forskning,Forskargrupper vid Lunds universitet,Obstetrics and Gynaecology (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Unit for translational obstetric research,Lund University Research Groups,Skåne University Hospital,Lund Univ, Sweden; Skane Univ Hosp, Sweden
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- Sturegård, Erik (author)
- Lund University,Lunds universitet,Klinisk infektionsmedicin,Forskargrupper vid Lunds universitet,Clinical infection medicine,Lund University Research Groups,Skåne University Hospital,Skane Univ Hosp, Sweden
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- Baqir, Haitham (author)
- Skåne University Hospital,Region Östergötland, Klinisk mikrobiologi
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- Westman, Anna (author)
- Karolinska University Hospital,Danderyd Hospital,Danderyd Hosp, Sweden; Karolinska Univ Hosp Lab, Sweden
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- Kjerstadius, Torbjörn (author)
- Karlstad Hospital,Cent Hosp Karlstad, Sweden
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- Schön, Thomas (author)
- Linköpings universitet,Linköping University,Avdelningen för inflammation och infektion,Medicinska fakulteten,Region Östergötland, Infektionskliniken i Östergötland,Department of Infectious Diseases, Kalmar County Hospital, Kalmar, Sweden
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- Björkman, Per (author)
- Lund University,Lunds universitet,Klinisk infektionsmedicin,Forskargrupper vid Lunds universitet,Clinical infection medicine,Lund University Research Groups,Skåne University Hospital,Lund Univ, Sweden; Skane Univ Hosp, Sweden
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(creator_code:org_t)
- OXFORD UNIV PRESS INC, 2024
- 2024
- English 8 s.
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In: Clinical Infectious Diseases. - : OXFORD UNIV PRESS INC. - 1058-4838 .- 1537-6591. ; 78:1, s. 125-132
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Abstract
Subject headings
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- Background: Tuberculosis (TB) disease has been associated with pregnancy complications. However, the potential impact of TB infection (TBI) on pregnancy outcome is unknown. To investigate this, we conducted a register-based study in immigrant women screened with QuantiFERON assays for TBI in antenatal care in Sweden. Methods: Women with history of immigration from TB-endemic countries were eligible for inclusion if national identification numbers and available QuantiFERON results obtained during pregnancy from 2014 to 2018 were available. QuantiFERON results were linked to data on maternal characteristics and pregnancy outcomes from the national Pregnancy and Patient Registers. TBI was defined as nil-corrected QuantiFERON result ≥0.35 IU/mL, in the absence of TB disease. Pregnancies in women with TB disease or human immunodeficiency virus were excluded, as were multiplex pregnancies, pregnancies resulting in miscarriage, and pregnancies occurring >10 years after immigration. Odds of defined adverse pregnancy outcomes were compared by maternal TBI status using mixed effects logistic regression with adjustment for maternal age and region of origin. Results: In total, 7408 women with 12 443 pregnancies were included. In multivariable analysis, stillbirth (adjusted odds ratio [AOR], 1.90; 95% confidence interval [CI], 1.13-3.21; P =. 016), severe preeclampsia (AOR, 1.62; 95% CI, 1.03-2.56; P =. 036), low birthweight (<2500 g; AOR, 1.38; 95% CI, 1.01-1.88; P =. 041), and emergency cesarean section (AOR, 1.28; 95% CI, 1.02-1.63; P =. 033) were significantly associated with TBI. Conclusions: Among immigrant women seeking antenatal care in Sweden, TBI was independently associated with adverse pregnancy outcomes. Further studies are needed to corroborate these findings and to explore mechanisms involved.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Keyword
- latent tuberculosis infection
- preeclampsia
- pregnancy
- stillbirth
- tuberculosis
- latent tuberculosis infection; tuberculosis; stillbirth; preeclampsia; pregnancy
Publication and Content Type
- art (subject category)
- ref (subject category)
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