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NK cells stimulate ...
NK cells stimulate proliferation of T and NK cells through 2B4/CD48 interactions
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- Assarsson, E (författare)
- Karolinska Institutet
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Kambayashi, T (författare)
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Schatzle, JD (författare)
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Cramer, SO (författare)
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von Bonin, A (författare)
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Jensen, PE (författare)
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- Ljunggren, HG (författare)
- Karolinska Institutet
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- Chambers, BJ (författare)
- Karolinska Institutet
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(creator_code:org_t)
- The American Association of Immunologists, 2004
- 2004
- Engelska.
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Ingår i: Journal of immunology (Baltimore, Md. : 1950). - : The American Association of Immunologists. - 0022-1767 .- 1550-6606. ; 173:1, s. 174-180
- Relaterad länk:
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http://www.jimmunol....
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http://kipublication...
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https://doi.org/10.4...
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Abstract
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- Few studies have addressed the consequences of physical interactions between NK and T cells, as well as physical interactions among NK cells themselves. We show in this study that NK cells can enhance T cell activation and proliferation in response to CD3 cross-linking and specific Ag through interactions between 2B4 (CD244) on NK cells and CD48 on T cells. Furthermore, 2B4/CD48 interactions between NK cells also enhanced proliferation of NK cells in response to IL-2. Overall, these results suggest that NK cells augment the proliferation of neighboring T and NK cells through direct cell-cell contact. These results provide new insights into NK cell-mediated control of innate and adaptive immunity and demonstrate that receptor/ligand-specific cross talk between lymphocytes may occur in settings other than T-B cell or T-T cell interactions.
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