Sökning: id:"swepub:oai:prod.swepub.kib.ki.se:116495856" >
Asthma, eczema, rhi...
Asthma, eczema, rhinitis and the risk for dementia
-
- Eriksson, UK (författare)
- Karolinska Institutet
-
Gatz, M (författare)
-
- Dickman, PW (författare)
- Karolinska Institutet
-
visa fler...
-
- Fratiglioni, L (författare)
- Karolinska Institutet
-
- Pedersen, NL (författare)
- Karolinska Institutet
-
visa färre...
-
(creator_code:org_t)
- 2007-12-20
- 2008
- Engelska.
-
Ingår i: Dementia and geriatric cognitive disorders. - : S. Karger AG. - 1421-9824 .- 1420-8008. ; 25:2, s. 148-156
- Relaterad länk:
-
http://kipublication...
-
visa fler...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- <i>Background:</i> Inflammation is associated with Alzheimer’s disease (AD) and dementia. In light of the chronic inflammatory properties of the atopic disorders asthma, eczema and rhinitis, we hypothesized an association with dementia. <i>Methods:</i> Self-reported asthma, eczema or rhinitis was assessed (prior to dementia follow-up) through questionnaires in the 1960s or 1970s in twins from the population-based Swedish Twin Registry. Dementia was assessed both longitudinally (n = 22,188), through linkages to two population-based registers, and cross-sectionally (n = 7,800), through telephone cognitive screening followed by a clinical evaluation of suspects of dementia. Risk ratios were estimated with Cox and logistic regression models controlling for vascular disease and genetic confounding. <i>Results:</i> In the longitudinal study, a history of atopy was positively associated with dementia (HR = 1.16; 1.01–1.33). In the cross-sectional study we found overall lower risks, none of which was statistically significant. Asthma was associated with a shorter survival time following AD onset. <i>Conclusions:</i> Atopy is associated with a modestly increased risk of AD and dementia that is not mediated by vascular disease or due to genetic confounding. A history of asthma is associated with shorter life expectancy after AD diagnosis.
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas