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Rate of ventricular...
Rate of ventricular enlargement in multiple sclerosis: a nine-year magnetic resonance imaging follow-up study
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Martola, J (författare)
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- Stawiarz, L (författare)
- Karolinska Institutet
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- Fredrikson, S (författare)
- Karolinska Institutet
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- Hillert, J (författare)
- Karolinska Institutet
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- Bergstrom, J (författare)
- Karolinska Institutet
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- Flodmark, O (författare)
- Karolinska Institutet
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- Aspelin, P (författare)
- Karolinska Institutet
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- Wiberg, MK (författare)
- Karolinska Institutet
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(creator_code:org_t)
- 2008-06-01
- 2008
- Engelska.
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Ingår i: Acta radiologica (Stockholm, Sweden : 1987). - : SAGE Publications. - 1600-0455 .- 0284-1851. ; 49:5, s. 570-579
- Relaterad länk:
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http://kipublication...
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https://doi.org/10.1...
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Abstract
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- Background: In multiple sclerosis (MS), brain atrophy assessed by linear measurements of ventricular widths has been reported to be well correlated with three-dimensional (3D) measurements. Therefore, serial linear measurements with no need for advanced 3D evaluation may be proven to be robust markers of irreversible, destructive changes. Purpose: To evaluate the rate of supratentorial ventricular enlargement representing four decades of disease span. Material and Methods: 37 MS patients with disease duration at baseline ranging from 1 to 33 years were included. The mean time of the individual magnetic resonance imaging (MRI) follow-up was 9.25 years (range 7.3–10 years). Enlargement rate of the third and lateral ventricles was studied over time by applying three linear measurements on axial 5-mm T1-weighted MRI images. Results: Progression of supratentorial ventricular widths during 9 years’ follow-up was found. The mean annual width increase of the third ventricle was 0.20 mm ( P<0.001, 95% confidence interval [CI] 0.15–0.25), for the frontal horn width 0.32 mm ( P<0.001, 95% CI 0.23–0.40), and increase of the intercaudate distance was 0.26 mm ( P<0.001, 95% CI 0.19–0.33). The association between these three measurements and disability status persisted at the time of follow-up. Conclusion: We found uniform ventricular enlargement progression during four decades of disease span, suggesting unchanging total brain atrophy progression over time.
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- art (ämneskategori)
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