Sökning: id:"swepub:oai:prod.swepub.kib.ki.se:117586198" >
Elevated numbers of...
Elevated numbers of Fc gamma RIIIA+ (CD16+) effector CD8 T cells with NK cell-like function in chronic hepatitis C virus infection
-
- Bjorkstrom, NK (författare)
- Karolinska Institutet
-
- Gonzalez, VD (författare)
- Karolinska Institutet
-
- Malmberg, KJ (författare)
- Karolinska Institutet
-
visa fler...
-
- Falconer, K (författare)
- Karolinska Institutet
-
Alaeus, A (författare)
-
- Nowak, G (författare)
- Karolinska Institutet
-
- Jorns, C (författare)
- Karolinska Institutet
-
- Ericzon, BG (författare)
- Karolinska Institutet
-
- Weiland, O (författare)
- Karolinska Institutet
-
- Sandberg, JK (författare)
- Karolinska Institutet
-
- Ljunggren, HG (författare)
- Karolinska Institutet
-
visa färre...
-
(creator_code:org_t)
- The American Association of Immunologists, 2008
- 2008
- Engelska.
-
Ingår i: Journal of immunology (Baltimore, Md. : 1950). - : The American Association of Immunologists. - 1550-6606 .- 0022-1767. ; 181:6, s. 4219-4228
- Relaterad länk:
-
http://www.jimmunol....
-
visa fler...
-
http://kipublication...
-
https://doi.org/10.4...
-
visa färre...
Abstract
Ämnesord
Stäng
- CTL are crucial in the defense against viral infections. In the course of investigating peripheral blood and intrahepatic CD8 T cells in patients with chronic hepatitis C virus (HCV) infection, we observed a significant population of CD8 T cells expressing the FcγRIIIA (CD16) receptor. This observation led us to characterize these cells with respect to their phenotype and function in a cohort of patients with chronic HCV infection as well as in healthy blood donors. On average, 10% of peripheral blood CD8 T cells from HCV-infected patients expressed CD16 compared with only a few percent in healthy donors. CD16+ CD8 T cells displayed a late-stage effector phenotype with high levels of perforin. These cells exhibited a restricted TCR profile suggesting underlying clonal expansion. Stimulation of CD16 on CD8 T cells evoked a vigorous response similar to that of CD16 stimulation in NK cells. Our data suggest that CD8 T cells, during chronic HCV infection in humans, continue to differentiate beyond defined stages of terminal effector cells, acquiring CD16 and NK cell-like functional properties.
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Bjorkstrom, NK
-
Gonzalez, VD
-
Malmberg, KJ
-
Falconer, K
-
Alaeus, A
-
Nowak, G
-
visa fler...
-
Jorns, C
-
Ericzon, BG
-
Weiland, O
-
Sandberg, JK
-
Ljunggren, HG
-
visa färre...
- Artiklar i publikationen
-
Journal of immun ...
- Av lärosätet
-
Karolinska Institutet