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T cell responses to...
T cell responses to mycobacterial catalase-peroxidase profile a pathogenic antigen in systemic sarcoidosis
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Chen, ES (författare)
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- Wahlstrom, J (författare)
- Karolinska Institutet
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Song, ZM (författare)
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Willett, MH (författare)
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- Wiken, M (författare)
- Karolinska Institutet
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Yung, RC (författare)
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West, EE (författare)
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McDyer, JF (författare)
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Zhang, Y (författare)
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- Eklund, A (författare)
- Karolinska Institutet
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- Grunewald, J (författare)
- Karolinska Institutet
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Moller, DR (författare)
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(creator_code:org_t)
- The American Association of Immunologists, 2008
- 2008
- Engelska.
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Ingår i: Journal of immunology (Baltimore, Md. : 1950). - : The American Association of Immunologists. - 1550-6606 .- 0022-1767. ; 181:12, s. 8784-8796
- Relaterad länk:
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https://www.jimmunol...
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http://kipublication...
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https://doi.org/10.4...
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Abstract
Ämnesord
Stäng
- Sarcoidosis is a systemic granulomatous disease associated with local epithelioid granulomas, CD4+ T cells, and Th1 cytokines. The tissue Ags that drive this granulomatous inflammation are uncertain. In this study, we used IFN-γ-ELISPOT assays and flow cytometry to assess lung and blood T cell responses to the candidate pathogenic Ag, Mycobacterium tuberculosis catalase-peroxidase (mKatG) in patients with sarcoidosis from two centers. Despite differences in patient phenotypic, genetic, and prognostic characteristics, we report that T cell responses to mKatG were remarkably similar in these cohorts, with higher frequencies of mKatG-reactive, IFN-γ-expressing T cells in the blood of sarcoidosis patients compared with nontuberculosis sensitized healthy controls, and (in a subset) in greater numbers than T cells reactive to purified protein derivative. In sarcoidosis, mKatG-reactive CD4+ Th1 cells preferentially accumulated in the lung, indicating a compartmentalized response. Patients with or without Löfgren syndrome had similar frequencies of mKatG specific IFN-γ-expressing blood T cells. Circulating mKatG-reactive T cells were found in chronic active sarcoidosis but not in patients with inactive disease. Together, these results demonstrate that T cell responses to mKatG in sarcoidosis fit a profile expected for a pathogenic Ag, supporting an immunotherapeutic approach to this disease.
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- art (ämneskategori)
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- Av författaren/redakt...
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Chen, ES
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Wahlstrom, J
-
Song, ZM
-
Willett, MH
-
Wiken, M
-
Yung, RC
-
visa fler...
-
West, EE
-
McDyer, JF
-
Zhang, Y
-
Eklund, A
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Grunewald, J
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Moller, DR
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visa färre...
- Artiklar i publikationen
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Journal of immun ...
- Av lärosätet
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Karolinska Institutet