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Family-based associ...
Family-based association study of the MCF2L2 gene and polycystic ovary syndrome
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Zheng, QM (författare)
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Shi, YH (författare)
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Yang, ZL (författare)
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Xu, XH (författare)
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Wang, LC (författare)
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Xue, FZ (författare)
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- Gu, HF (författare)
- Karolinska Institutet
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Chen, ZJ (författare)
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(creator_code:org_t)
- 2009-07-31
- 2009
- Engelska.
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Ingår i: Gynecologic and obstetric investigation. - : S. Karger AG. - 1423-002X .- 0378-7346. ; 68:3, s. 171-173
- Relaterad länk:
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http://kipublication...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- <i>Objective:</i> The aim of the study was to determine the association between three single nucleotide polymorphism (SNP) variants (rs35368790, rs35069869 and rs684846) of the MCF2 cell line-derived transforming sequence-like 2 <i>(MCF2L2)</i> gene and polycystic ovary syndrome (PCOS) in PCOS family trios. <i>Methods:</i> Genotyping was done by TaqMan assay that incorporates minor groove-binding probe technology for allelic discrimination. One hundred and fifty-two unrelated PCOS probands and their biological parents were recruited. All subjects were of Han Chinese origin and from Shandong Province. <i>Results:</i> The transmission disequilibrium test (TDT) for allelic association demonstrated that a weak association was detected in SNP rs35368790 with p = 0.008. However, we found no significant transmission distortion of the other two SNPs (rs35069869, χ<sup>2</sup> = 3.645, p = 0.056; rs684846, χ<sup>2</sup> = 1.429, p = 0.232, respectively). <i>Conclusions:</i> These results suggest that the genetic polymorphisms within <i>MCF2L2</i> are likely to confer an increased susceptibility to PCOS in the Chinese population. Our present data may provide a basis for further studies of the role of the <i>MCF2L2</i> gene in the etiology of PCOS.
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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