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PtdIns(3,4,5)P₃ is ...
PtdIns(3,4,5)P₃ is a regulator of myosin-X localization and filopodia formation
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Plantard, L (författare)
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Arjonen, A (författare)
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- Lock, JG (författare)
- Karolinska Institutet
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Nurani, G (författare)
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Ivaska, J (författare)
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- Stromblad, S (författare)
- Karolinska Institutet
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(creator_code:org_t)
- The Company of Biologists, 2010
- 2010
- Engelska.
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Ingår i: Journal of cell science. - : The Company of Biologists. - 1477-9137 .- 0021-9533. ; 123:20Pt 20, s. 3525-3534
- Relaterad länk:
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http://jcs.biologist...
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http://kipublication...
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https://doi.org/10.1...
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Abstract
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- Phosphatidylinositol (3,4,5)-trisphosphate [PtdIns(3,4,5)P3] is a key regulator of cell signaling that acts by recruiting proteins to the cell membrane, such as at the leading edge during cell migration. Here, we show that PtdIns (3,4,5)P3 plays a central role in filopodia formation via the binding of myosin-X (Myo10), a potent promoter of filopodia. We found that the second pleckstrin homology domain (Myo10-PH2) of Myo10 specifically binds to PtdIns(3,4,5)P3, and that disruption of this binding led to impairment of filopodia and partial re-localization of Myo10 to microtubule-associated Rab7-positive endosomal vesicles. Given that the localization of Myo10 was dynamically restored to filopodia upon reinstatement of PtdIns(3,4,5)P3-binding, our results indicate that PtdIns(3,4,5)P3 binding to the Myo10-PH2 domain is involved in Myo10 trafficking and regulation of filopodia dynamics.
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