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CYP2C19 genotype pr...
CYP2C19 genotype predicts steady state escitalopram concentration in GENDEP
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Huezo-Diaz, P (författare)
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Perroud, N (författare)
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Spencer, EP (författare)
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visa fler...
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Smith, R (författare)
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- Sim, S (författare)
- Karolinska Institutet
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Virding, S (författare)
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Uher, R (författare)
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Gunasinghe, C (författare)
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Gray, J (författare)
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Campbell, D (författare)
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Hauser, J (författare)
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Maier, W (författare)
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Marusic, A (författare)
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Rietschel, M (författare)
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Perez, J (författare)
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Giovannini, C (författare)
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Mors, O (författare)
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Mendlewicz, J (författare)
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McGuffin, P (författare)
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Farmer, AE (författare)
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- Ingelman-Sundberg, M (författare)
- Karolinska Institutet
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Craig, IW (författare)
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Aitchison, KJ (författare)
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(creator_code:org_t)
- 2011-09-17
- 2012
- Engelska.
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Ingår i: Journal of psychopharmacology (Oxford, England). - : SAGE Publications. - 1461-7285 .- 0269-8811. ; 26:3, s. 398-407
- Relaterad länk:
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http://kipublication...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- In vitro work shows CYP2C19 and CYP2D6 contribute to the metabolism of escitalopram to its primary metabolite, N-desmethylescitalopram. We report the effect of CYP2C19 and CYP2D6 genotypes on steady state morning concentrations of escitalopram and N-desmethylescitalopram and the ratio of this metabolite to the parent drug in 196 adult patients with depression in GENDEP, a clinical pharmacogenomic trial. Subjects who had one CYP2D6 allele associated with intermediate metabolizer phenotype and one associated with poor metabolizer (i.e. IM/PM genotypic category) had a higher mean logarithm escitalopram concentration than CYP2D6 extensive metabolizers (EMs) ( p = 0.004). Older age was also associated with higher concentrations of escitalopram. Covarying for CYP2D6 and age, we found those homozygous for the CYP2C19*17 allele associated with ultrarapid metabolizer (UM) phenotype had a significantly lower mean escitalopram concentration (2-fold, p = 0.0001) and a higher mean metabolic ratio ( p = 0.0003) than EMs, while those homozygous for alleles conferring the PM phenotype had a higher mean escitalopram concentration than EMs (1.55-fold, p = 0.008). There was a significant overall association between CYP2C19 genotypic category and escitalopram concentration ( p = 0.0003; p = 0.0012 Bonferroni corrected). In conclusion, we have demonstrated an association between CYP2C19 genotype, including the CYP2C19*17 allele, and steady state escitalopram concentration.
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- art (ämneskategori)
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- Av författaren/redakt...
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Huezo-Diaz, P
-
Perroud, N
-
Spencer, EP
-
Smith, R
-
Sim, S
-
Virding, S
-
visa fler...
-
Uher, R
-
Gunasinghe, C
-
Gray, J
-
Campbell, D
-
Hauser, J
-
Maier, W
-
Marusic, A
-
Rietschel, M
-
Perez, J
-
Giovannini, C
-
Mors, O
-
Mendlewicz, J
-
McGuffin, P
-
Farmer, AE
-
Ingelman-Sundber ...
-
Craig, IW
-
Aitchison, KJ
-
visa färre...
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Journal of psych ...
- Av lärosätet
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Karolinska Institutet