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Differential roles ...
Differential roles of epigenetic changes and Foxp3 expression in regulatory T cell-specific transcriptional regulation
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Morikawa, H (författare)
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Ohkura, N (författare)
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Vandenbon, A (författare)
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Itoh, M (författare)
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Nagao-Sato, S (författare)
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Kawaji, H (författare)
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Lassmann, T (författare)
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Carninci, P (författare)
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Hayashizaki, Y (författare)
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Forrest, ARR (författare)
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Standley, DM (författare)
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Date, H (författare)
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Sakaguchi, S (författare)
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- 2014-03-27
- 2014
- Engelska.
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Ingår i: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 1091-6490. ; 111:14, s. 5289-5294
- Relaterad länk:
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https://www.pnas.org...
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http://kipublication...
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https://doi.org/10.1...
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Abstract
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- Naturally occurring regulatory T (Treg) cells, which specifically express the transcription factor forkhead box P3 (Foxp3), are engaged in the maintenance of immunological self-tolerance and homeostasis. By transcriptional start site cluster analysis, we assessed here how genome-wide patterns of DNA methylation or Foxp3 binding sites were associated with Treg-specific gene expression. We found that Treg-specific DNA hypomethylated regions were closely associated with Treg up-regulated transcriptional start site clusters, whereas Foxp3 binding regions had no significant correlation with either up- or down-regulated clusters in nonactivated Treg cells. However, in activated Treg cells, Foxp3 binding regions showed a strong correlation with down-regulated clusters. In accordance with these findings, the above two features of activation-dependent gene regulation in Treg cells tend to occur at different locations in the genome. The results collectively indicate that Treg-specific DNA hypomethylation is instrumental in gene up-regulation in steady state Treg cells, whereas Foxp3 down-regulates the expression of its target genes in activated Treg cells. Thus, the two events seem to play distinct but complementary roles in Treg-specific gene expression.
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- art (ämneskategori)
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- Av författaren/redakt...
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Morikawa, H
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Ohkura, N
-
Vandenbon, A
-
Itoh, M
-
Nagao-Sato, S
-
Kawaji, H
-
visa fler...
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Lassmann, T
-
Carninci, P
-
Hayashizaki, Y
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Forrest, ARR
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Standley, DM
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Date, H
-
Sakaguchi, S
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visa färre...
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- Av lärosätet
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Karolinska Institutet