Sökning: id:"swepub:oai:prod.swepub.kib.ki.se:136551013" >
Meta-signature of h...
Meta-signature of human endometrial receptivity: a meta-analysis and validation study of transcriptomic biomarkers
-
Altmae, S (författare)
-
Koel, M (författare)
-
Vosa, U (författare)
-
visa fler...
-
Adler, P (författare)
-
Suhorutsenko, M (författare)
-
Laisk-Podar, T (författare)
-
Kukushkina, V (författare)
-
Saare, M (författare)
-
Velthut-Meikas, A (författare)
-
Krjutskov, K (författare)
-
Aghajanova, L (författare)
-
- Lalitkumar, PG (författare)
- Karolinska Institutet
-
- Gemzell-Danielsson, K (författare)
- Karolinska Institutet
-
Giudice, L (författare)
-
Simon, C (författare)
-
Salumets, A (författare)
-
visa färre...
-
(creator_code:org_t)
- 2017-08-30
- 2017
- Engelska.
-
Ingår i: Scientific reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 7:1, s. 10077-
- Relaterad länk:
-
https://www.nature.c...
-
visa fler...
-
http://kipublication...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Previous transcriptome studies of the human endometrium have revealed hundreds of simultaneously up- and down-regulated genes that are involved in endometrial receptivity. However, the overlap between the studies is relatively small, and we are still searching for potential diagnostic biomarkers. Here we perform a meta-analysis of endometrial-receptivity associated genes on 164 endometrial samples (76 from ‘pre-receptive’ and 88 from mid-secretory, ‘receptive’ phase endometria) using a robust rank aggregation (RRA) method, followed by enrichment analysis, and regulatory microRNA prediction. We identify a meta-signature of endometrial receptivity involving 57 mRNA genes as putative receptivity markers, where 39 of these we confirm experimentally using RNA-sequencing method in two separate datasets. The meta-signature genes highlight the importance of immune responses, the complement cascade pathway and the involvement of exosomes in mid-secretory endometrial functions. Bioinformatic prediction identifies 348 microRNAs that could regulate 30 endometrial-receptivity associated genes, and we confirm experimentally the decreased expression of 19 microRNAs with 11 corresponding up-regulated meta-signature genes in our validation experiments. The 57 identified meta-signature genes and involved pathways, together with their regulatory microRNAs could serve as promising and sought-after biomarkers of endometrial receptivity, fertility and infertility.
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Altmae, S
-
Koel, M
-
Vosa, U
-
Adler, P
-
Suhorutsenko, M
-
Laisk-Podar, T
-
visa fler...
-
Kukushkina, V
-
Saare, M
-
Velthut-Meikas, ...
-
Krjutskov, K
-
Aghajanova, L
-
Lalitkumar, PG
-
Gemzell-Danielss ...
-
Giudice, L
-
Simon, C
-
Salumets, A
-
visa färre...
- Artiklar i publikationen
-
Scientific repor ...
- Av lärosätet
-
Karolinska Institutet