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Genetic variation i...
Genetic variation in 117 myelination-related genes in schizophrenia: Replication of association to lipid biosynthesis genes
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Stokowy, T (författare)
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Polushina, T (författare)
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Sonderby, IE (författare)
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- Karlsson, R (författare)
- Karolinska Institutet
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Giddaluru, S (författare)
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Le Hellard, S (författare)
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- Bergen, SE (författare)
- Karolinska Institutet
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- Sullivan, PF (författare)
- Karolinska Institutet
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Andreassen, OA (författare)
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Djurovic, S (författare)
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- Hultman, CM (författare)
- Karolinska Institutet
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Steen, VM (författare)
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(creator_code:org_t)
- 2018-05-02
- 2018
- Engelska.
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Ingår i: Scientific reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 8:1, s. 6915-
- Relaterad länk:
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https://www.nature.c...
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http://kipublication...
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https://doi.org/10.1...
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Abstract
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- Schizophrenia is a serious psychotic disorder with high heritability. Several common genetic variants, rare copy number variants and ultra-rare gene-disrupting mutations have been linked to disease susceptibility, but there is still a large gap between the estimated and explained heritability. Since several studies have indicated brain myelination abnormalities in schizophrenia, we aimed to examine whether variants in myelination-related genes could be associated with risk for schizophrenia. We established a set of 117 myelination genes by database searches and manual curation. We used a combination of GWAS (SCZ_N = 35,476; CTRL_N = 46,839), exome chip (SCZ_N = 269; CTRL_N = 336) and exome sequencing data (SCZ_N = 2,527; CTRL_N = 2,536) from schizophrenia cases and healthy controls to examine common and rare variants. We found that a subset of lipid-related genes was nominally associated with schizophrenia (p = 0.037), but this signal did not survive multiple testing correction (FWER = 0.16) and was mainly driven by the SREBF1 and SREBF2 genes that have already been linked to schizophrenia. Further analysis demonstrated that the lowest nominal p-values were p = 0.0018 for a single common variant (rs8539) and p = 0.012 for burden of rare variants (LRP1 gene), but none of them survived multiple testing correction. Our findings suggest that variation in myelination-related genes is not a major risk factor for schizophrenia.
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- ref (ämneskategori)
- art (ämneskategori)
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Stokowy, T
-
Polushina, T
-
Sonderby, IE
-
Karlsson, R
-
Giddaluru, S
-
Le Hellard, S
-
visa fler...
-
Bergen, SE
-
Sullivan, PF
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Andreassen, OA
-
Djurovic, S
-
Hultman, CM
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Steen, VM
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visa färre...
- Artiklar i publikationen
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Scientific repor ...
- Av lärosätet
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Karolinska Institutet