VEGF-B is a potent antioxidant

• Despite being discovered a long time ago, the functional properties of VEGF-B remain poorly understood. However, several clinical treatments use drugs that target VEGF-B and other VEGF family members. It is therefore crucial to gain deeper insights into the function of VEGF-B and the underlying mechanisms. Here, we found that VEGF-B has potent antioxidative functions, making it a VEGF family member to show such a property. We further identified a critical downstream effector of VEGF-B, Gpx1, through which it protects against retinal degeneration. In addition, being an otherwise “inert” molecule, as shown by previous studies, makes VEGF-B a promising molecule for clinical applications. Our findings suggest that VEGF-B could be a potent therapeutic agent against oxidative stress-related diseases.

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)