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Genetic models reve...
Genetic models reveal origin, persistence and non-redundant functions of IL-17-producing γδ T cells
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Sandrock, I (author)
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- Reinhardt, A (author)
- Karolinska Institutet
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Ravens, S (author)
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Binz, C (author)
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Wilharm, A (author)
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Martins, J (author)
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Oberdorfer, L (author)
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Tan, LK (author)
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Lienenklaus, S (author)
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Zhang, BJ (author)
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Naumann, R (author)
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Zhuang, Y (author)
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Krueger, A (author)
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Forster, R (author)
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Prinz, I (author)
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(creator_code:org_t)
- 2018-11-19
- 2018
- English.
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In: The Journal of experimental medicine. - : Rockefeller University Press. - 1540-9538 .- 0022-1007. ; 215:12, s. 3006-3018
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https://rupress.org/...
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http://kipublication...
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https://doi.org/10.1...
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Abstract
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- γδ T cells are highly conserved in jawed vertebrates, suggesting an essential role in the immune system. However, γδ T cell–deficient Tcrd−/− mice display surprisingly mild phenotypes. We hypothesized that the lack of γδ T cells in constitutive Tcrd−/− mice is functionally compensated by other lymphocytes taking over genuine γδ T cell functions. To test this, we generated a knock-in model for diphtheria toxin–mediated conditional γδ T cell depletion. In contrast to IFN-γ–producing γδ T cells, IL-17–producing γδ T cells (Tγδ17 cells) recovered inefficiently after depletion, and their niches were filled by expanding Th17 cells and ILC3s. Complementary genetic fate mapping further demonstrated that Tγδ17 cells are long-lived and persisting lymphocytes. Investigating the function of γδ T cells, conditional depletion but not constitutive deficiency protected from imiquimod-induced psoriasis. Together, we clarify that fetal thymus-derived Tγδ17 cells are nonredundant local effector cells in IL-17–driven skin pathology.
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- By the author/editor
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Sandrock, I
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Reinhardt, A
-
Ravens, S
-
Binz, C
-
Wilharm, A
-
Martins, J
-
show more...
-
Oberdorfer, L
-
Tan, LK
-
Lienenklaus, S
-
Zhang, BJ
-
Naumann, R
-
Zhuang, Y
-
Krueger, A
-
Forster, R
-
Prinz, I
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show less...
- Articles in the publication
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The Journal of e ...
- By the university
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Karolinska Institutet