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Effect of childhood...
Effect of childhood pneumococcal conjugate vaccination on invasive disease in older adults of 10 European countries: implications for adult vaccination
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Hanquet, G (författare)
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Krizova, P (författare)
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Valentiner-Branth, P (författare)
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visa fler...
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Ladhani, SN (författare)
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Nuorti, JP (författare)
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Lepoutre, A (författare)
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Mereckiene, J (författare)
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Knol, M (författare)
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Winje, BA (författare)
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Ciruela, P (författare)
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Ordobas, M (författare)
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Guevara, M (författare)
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McDonald, E (författare)
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Morfeldt, E (författare)
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Kozakova, J (författare)
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Slotved, HC (författare)
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Fry, NK (författare)
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Rinta-Kokko, H (författare)
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Varon, E (författare)
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Corcoran, M (författare)
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van der Ende, A (författare)
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Vestrheim, DF (författare)
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Munoz-Almagro, C (författare)
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Latasa, P (författare)
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Castilla, J (författare)
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Smith, A (författare)
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- Henriques-Normark, B (författare)
- Karolinska Institutet
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Whittaker, R (författare)
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Celentano, LP (författare)
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Savulescu, C (författare)
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(creator_code:org_t)
- 2018-10-24
- 2019
- Engelska.
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Ingår i: Thorax. - : BMJ. - 1468-3296 .- 0040-6376. ; 74:5, s. 473-482
- Relaterad länk:
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https://thorax.bmj.c...
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http://kipublication...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- Pneumococcal conjugate vaccines (PCVs) have the potential to prevent pneumococcal disease through direct and indirect protection. This multicentre European study estimated the indirect effects of 5-year childhood PCV10 and/or PCV13 programmes on invasive pneumococcal disease (IPD) in older adults across 13 sites in 10 European countries, to support decision-making on pneumococcal vaccination policies.MethodsFor each site we calculated IPD incidence rate ratios (IRR) in people aged ≥65 years by serotype for each PCV10/13 year (2011–2015) compared with 2009 (pre-PCV10/13). We calculated pooled IRR and 95% CI using random-effects meta-analysis and PCV10/13 effect as (1 − IRR)*100.ResultsAfter five PCV10/13 years, the incidence of IPD caused by all types, PCV7 and additional PCV13 serotypes declined 9% (95% CI −4% to 19%), 77% (95% CI 67% to 84%) and 38% (95% CI 19% to 53%), respectively, while the incidence of non-PCV13 serotypes increased 63% (95% CI 39% to 91%). The incidence of serotypes included in PCV13 and not in PCV10 decreased 37% (95% CI 22% to 50%) in six PCV13 sites and increased by 50% (95% CI −8% to 146%) in the four sites using PCV10 (alone or with PCV13). In 2015, PCV13 serotypes represented 20–29% and 32–53% of IPD cases in PCV13 and PCV10 sites, respectively.ConclusionOverall IPD incidence in older adults decreased moderately after five childhood PCV10/13 years in 13 European sites. Large declines in PCV10/13 serotype IPD, due to the indirect effect of childhood vaccination, were countered by increases in non-PCV13 IPD, but these declines varied according to the childhood vaccine used. Decision-making on pneumococcal vaccination for older adults must consider the indirect effects of childhood PCV programmes. Sustained monitoring of IPD epidemiology is imperative.
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Thorax
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Till lärosätets databas
- Av författaren/redakt...
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Hanquet, G
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Krizova, P
-
Valentiner-Brant ...
-
Ladhani, SN
-
Nuorti, JP
-
Lepoutre, A
-
visa fler...
-
Mereckiene, J
-
Knol, M
-
Winje, BA
-
Ciruela, P
-
Ordobas, M
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Guevara, M
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McDonald, E
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Morfeldt, E
-
Kozakova, J
-
Slotved, HC
-
Fry, NK
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Rinta-Kokko, H
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Varon, E
-
Corcoran, M
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van der Ende, A
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Vestrheim, DF
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Munoz-Almagro, C
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Latasa, P
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Castilla, J
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Smith, A
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Henriques-Normar ...
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Whittaker, R
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Celentano, LP
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Savulescu, C
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visa färre...
- Artiklar i publikationen
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Thorax
- Av lärosätet
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Karolinska Institutet