Sökning: id:"swepub:oai:prod.swepub.kib.ki.se:141266031" >
Modified UCN2 Pepti...
Modified UCN2 Peptide Acts as an Insulin Sensitizer in Skeletal Muscle of Obese Mice
-
Borg, ML (författare)
-
Massart, J (författare)
-
Schonke, M (författare)
-
visa fler...
-
- Barbosa, TD (författare)
- Karolinska Institutet
-
Guo, LL (författare)
-
Wade, M (författare)
-
Alsina-Fernandez, J (författare)
-
Miles, R (författare)
-
Ryan, A (författare)
-
Bauer, S (författare)
-
Coskun, T (författare)
-
O'Farrell, E (författare)
-
Niemeier, EM (författare)
-
- Chibalin, AV (författare)
- Karolinska Institutet
-
- Krook, A (författare)
- Karolinska Institutet
-
- Karlsson, HK (författare)
- Karolinska Institutet
-
Brozinick, JT (författare)
-
- Zierath, JR (författare)
- Karolinska Institutet
-
visa färre...
-
(creator_code:org_t)
- 2019-04-22
- 2019
- Engelska.
-
Ingår i: Diabetes. - : American Diabetes Association. - 1939-327X .- 0012-1797. ; 68:7, s. 1403-1414
- Relaterad länk:
-
https://diabetes.dia...
-
visa fler...
-
http://kipublication...
-
https://doi.org/10.2...
-
visa färre...
Abstract
Ämnesord
Stäng
- The neuropeptide urocortin 2 (UCN2) and its receptor corticotropin-releasing hormone receptor 2 (CRHR2) are highly expressed in skeletal muscle and play a role in regulating energy balance and glucose metabolism. We investigated a modified UCN2 peptide as a potential therapeutic agent for the treatment of obesity and insulin resistance, with a specific focus on skeletal muscle. High-fat–fed mice (C57BL/6J) were injected daily with a PEGylated UCN2 peptide (compound A) at 0.3 mg/kg subcutaneously for 14 days. Compound A reduced body weight, food intake, whole-body fat mass, and intramuscular triglycerides compared with vehicle-treated controls. Furthermore, whole-body glucose tolerance was improved by compound A treatment, with increased insulin-stimulated Akt phosphorylation at Ser473 and Thr308 in skeletal muscle, concomitant with increased glucose transport into extensor digitorum longus and gastrocnemius muscle. Mechanistically, this is linked to a direct effect on skeletal muscle because ex vivo exposure of soleus muscle from chow-fed lean mice to compound A increased glucose transport and insulin signaling. Moreover, exposure of GLUT4-Myc–labeled L6 myoblasts to compound A increased GLUT4 trafficking. Our results demonstrate that modified UCN2 peptides may be efficacious in the treatment of type 2 diabetes by acting as an insulin sensitizer in skeletal muscle.
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
-
Diabetes
(Sök värdpublikationen i LIBRIS)
Till lärosätets databas
- Av författaren/redakt...
-
Borg, ML
-
Massart, J
-
Schonke, M
-
Barbosa, TD
-
Guo, LL
-
Wade, M
-
visa fler...
-
Alsina-Fernandez ...
-
Miles, R
-
Ryan, A
-
Bauer, S
-
Coskun, T
-
O'Farrell, E
-
Niemeier, EM
-
Chibalin, AV
-
Krook, A
-
Karlsson, HK
-
Brozinick, JT
-
Zierath, JR
-
visa färre...
- Artiklar i publikationen
-
Diabetes
- Av lärosätet
-
Karolinska Institutet