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Stroke in the Middl...
Stroke in the Middle-East and North Africa: A 2-year prospective observational study of intravenous thrombolysis treatment in the region. Results from the SITS-MENA Registry
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Al-Rukn, S (författare)
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- Mazya, M (författare)
- Karolinska Institutet
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Akhtar, N (författare)
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Hashim, H (författare)
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Mansouri, B (författare)
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Faouzi, B (författare)
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Aref, H (författare)
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Abdulrahman, H (författare)
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Kesraoui, S (författare)
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Hentati, F (författare)
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Gebelly, S (författare)
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- Ahmed, N (författare)
- Karolinska Institutet
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- Wahlgren, N (författare)
- Karolinska Institutet
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Abd-Allah, F (författare)
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Almekhlafi, M (författare)
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- Moreira, T (författare)
- Karolinska Institutet
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(creator_code:org_t)
- 2019-10-08
- 2020
- Engelska.
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Ingår i: International journal of stroke : official journal of the International Stroke Society. - : SAGE Publications. - 1747-4949. ; 15:9, s. 980-987
- Relaterad länk:
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http://kipublication...
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https://doi.org/10.1...
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Abstract
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- Intravenous thrombolysis for acute ischemic stroke in the Middle-East and North African (MENA) countries is still confined to the main urban and university hospitals. This was a prospective observational study to examine outcomes of intravenous thrombolysis-treated stroke patients in the MENA region compared to the non-MENA stroke cohort in the SITS International Registry. Results Of 32,160 patients with ischemic stroke registered using the SITS intravenous thrombolysis protocol between June 2014 and May 2016, 500 (1.6%) were recruited in MENA. Compared to non-MENA (all p < 0.001), median age in MENA was 55 versus 73 years, NIH Stroke Scale score 12 versus 9, onset-to-treatment time 138 versus 155 min and door-to-needle time 54 min versus 64 min. Hypertension was the most reported risk factor, but lower in MENA (51.7 vs. 69.7%). Diabetes was more frequent in MENA (28.5 vs. 20.8%) as well as smoking (20.8 vs. 15.9%). Hyperlipidemia was less observed in MENA (17.6 vs. 29.3%). Functional independence (mRS 0–2) at seven days or discharge was similar (53% vs. 52% in non-MENA), with mortality slightly lower in MENA (2.3% vs. 4.8%). SICH rates by SITS-MOST definition were low (<1.4%) in both groups. Conclusions Intravenous thrombolysis patients in MENA were younger, had more severe strokes and more often diabetes. Although stroke severity was higher in MENA, short-term functional independency and mortality were not worse compared to non-MENA, which could partly be explained by younger age and shorter OTT in MENA. Decreasing the burden of stroke in this young population should be prioritized.
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Al-Rukn, S
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Mazya, M
-
Akhtar, N
-
Hashim, H
-
Mansouri, B
-
Faouzi, B
-
visa fler...
-
Aref, H
-
Abdulrahman, H
-
Kesraoui, S
-
Hentati, F
-
Gebelly, S
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Ahmed, N
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Wahlgren, N
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Abd-Allah, F
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Almekhlafi, M
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Moreira, T
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visa färre...
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Karolinska Institutet