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STAT3 Activity Prom...
STAT3 Activity Promotes Programmed-Death Ligand 1 Expression and Suppresses Immune Responses in Breast Cancer
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- Zerdes, I (författare)
- Karolinska Institutet
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Wallerius, M (författare)
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- Sifakis, EG (författare)
- Karolinska Institutet
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visa fler...
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Wallmann, T (författare)
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Betts, S (författare)
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- Bartish, M (författare)
- Karolinska Institutet
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- Tsesmetzis, N (författare)
- Karolinska Institutet
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- Tobin, NP (författare)
- Karolinska Institutet
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- Coucoravas, C (författare)
- Karolinska Institutet
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- Bergh, J (författare)
- Karolinska Institutet
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- Rassidakis, GZ (författare)
- Karolinska Institutet
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- Rolny, C (författare)
- Karolinska Institutet
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- Foukakis, T (författare)
- Karolinska Institutet
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(creator_code:org_t)
- 2019-10-01
- 2019
- Engelska.
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Ingår i: Cancers. - : MDPI AG. - 2072-6694. ; 11:10
- Relaterad länk:
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https://doi.org/10.3...
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http://kipublication...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- Signal transducer and activator of transcription 3 (STAT3) is an oncogene and multifaceted transcription factor involved in multiple cellular functions. Its role in modifying anti-tumor immunity has been recently recognized. In this study, the biologic effects of STAT3 on immune checkpoint expression and anti-tumor responses were investigated in breast cancer (BC). A transcriptional signature of phosphorylated STAT3 was positively correlated with PD-L1 expression in two independent cohorts of early BC. Pharmacologic inhibition and gene silencing of STAT3 led to decreased Programmed Death Ligand 1 (PD-L1) expression levels in vitro, and resulted as well in reduction of tumor growth and decreased metastatic dissemination in a mammary carcinoma mouse model. The hampering of tumor progression was correlated to an anti-tumoral macrophage phenotype and accumulation of natural-killer cells, but also in reduced accrual of cytotoxic lymphocytes. In human BC, pro-tumoral macrophages correlated to PD-L1 expression, proliferation status and higher grade of malignancy, indicating a subset of patients with immunosuppressive properties. In conclusion, this study provides evidence for STAT3-mediated regulation of PD-L1 and modulation of immune microenvironment in BC.
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
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Cancers
(Sök värdpublikationen i LIBRIS)
Till lärosätets databas
- Av författaren/redakt...
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Zerdes, I
-
Wallerius, M
-
Sifakis, EG
-
Wallmann, T
-
Betts, S
-
Bartish, M
-
visa fler...
-
Tsesmetzis, N
-
Tobin, NP
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Coucoravas, C
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Bergh, J
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Rassidakis, GZ
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Rolny, C
-
Foukakis, T
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visa färre...
- Artiklar i publikationen
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Cancers
- Av lärosätet
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Karolinska Institutet