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Early modulation of...
Early modulation of macrophage ROS-PPARγ-NF-κB signalling by sonodynamic therapy attenuates neointimal hyperplasia in rabbits
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Yao, JT (författare)
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Zhao, XZ (författare)
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Tan, FC (författare)
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visa fler...
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Cao, XR (författare)
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Guo, SY (författare)
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Li, X (författare)
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Huang, Z (författare)
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Diabakte, K (författare)
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Wang, L (författare)
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Liu, MY (författare)
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Shen, ZQ (författare)
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Li, BC (författare)
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Cao, ZY (författare)
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Sheng, SQ (författare)
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Lu, MQ (författare)
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Cao, Y (författare)
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- Jin, H (författare)
- Karolinska Institutet
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Zhang, ZG (författare)
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Tian, Y (författare)
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(creator_code:org_t)
- 2020-07-15
- 2020
- Engelska.
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Ingår i: Scientific reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 10:1, s. 11638-
- Relaterad länk:
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https://www.nature.c...
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http://kipublication...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Disruption of re-endothelialization and haemodynamic balance remains a critical side effect of drug-eluting stents (DES) for preventing intimal hyperplasia. Previously, we found that 5-aminolevulinic acid-mediated sonodynamic therapy (ALA-SDT) suppressed macrophage-mediated inflammation in atherosclerotic plaques. However, the effects on intimal hyperplasia and re-endothelialization remain unknown. In this study, 56 rabbits were randomly assigned to control, ultrasound, ALA and ALA-SDT groups, and each group was divided into two subgroups (n = 7) on day 3 after right femoral artery balloon denudation combined with a hypercholesterolemic diet. Histopathological analysis revealed that ALA-SDT enhanced macrophage apoptosis and ameliorated inflammation from day 1. ALA-SDT inhibited neointima formation without affecting re-endothelialization, increased blood perfusion, decreased the content of macrophages, proliferating smooth muscle cells (SMCs) and collagen but increased elastin by day 28. In vitro, ALA-SDT induced macrophage apoptosis and reduced TNF-α, IL-6 and IL-1β via the ROS-PPARγ-NF-κB signalling pathway, which indirectly inhibited human umbilical artery smooth muscle cell (HUASMC) proliferation, migration and IL-6 production. ALA-SDT effectively inhibits intimal hyperplasia without affecting re-endothelialization. Hence, its clinical application combined with bare-metal stent (BMS) implantation presents a potential strategy to decrease bleeding risk caused by prolonged dual-antiplatelet regimen after DES deployment.
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- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Yao, JT
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Zhao, XZ
-
Tan, FC
-
Cao, XR
-
Guo, SY
-
Li, X
-
visa fler...
-
Huang, Z
-
Diabakte, K
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Wang, L
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Liu, MY
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Shen, ZQ
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Li, BC
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Cao, ZY
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Sheng, SQ
-
Lu, MQ
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Cao, Y
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Jin, H
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Zhang, ZG
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Tian, Y
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visa färre...
- Artiklar i publikationen
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Scientific repor ...
- Av lärosätet
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Karolinska Institutet