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The role of the com...
The role of the comprehensive complication index for the prediction of survival after liver transplantation
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Lai, Q (författare)
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Melandro, F (författare)
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- Nowak, G (författare)
- Karolinska Institutet
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Nicolini, D (författare)
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Iesari, S (författare)
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Fasolo, E (författare)
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Mennini, G (författare)
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- Romano, A (författare)
- Karolinska Institutet
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Mocchegiani, F (författare)
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Ackenine, K (författare)
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Polacco, M (författare)
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Marinelli, L (författare)
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Ciccarelli, O (författare)
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Zanus, G (författare)
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Vivarelli, M (författare)
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Cillo, U (författare)
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Rossi, M (författare)
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- Ericzon, BG (författare)
- Karolinska Institutet
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Lerut, J (författare)
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(creator_code:org_t)
- 2020-09-06
- 2021
- Engelska.
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Ingår i: Updates in surgery. - : Springer Science and Business Media LLC. - 2038-3312 .- 2038-131X. ; 73:1, s. 209-221
- Relaterad länk:
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https://link.springe...
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http://kipublication...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- In the last years, several scoring systems based on pre- and post-transplant parameters have been developed to predict early post-LT graft function. However, some of them showed poor diagnostic abilities. This study aims to evaluate the role of the comprehensive complication index (CCI) as a useful scoring system for accurately predicting 90-day and 1-year graft loss after liver transplantation. A training set (n = 1262) and a validation set (n = 520) were obtained. The study was registered at https://www.ClinicalTrials.gov (ID: NCT03723317). CCI exhibited the best diagnostic performance for 90 days in the training (AUC = 0.94; p < 0.001) and Validation Sets (AUC = 0.77; p < 0.001) when compared to the BAR, D-MELD, MELD, and EAD scores. The cut-off value of 47.3 (third quartile) showed a diagnostic odds ratio of 48.3 and 7.0 in the two sets, respectively. As for 1-year graft loss, CCI showed good performances in the training (AUC = 0.88; p < 0.001) and validation sets (AUC = 0.75; p < 0.001). The threshold of 47.3 showed a diagnostic odds ratio of 21.0 and 5.4 in the two sets, respectively. All the other tested scores always showed AUCs < 0.70 in both the sets. CCI showed a good stratification ability in terms of graft loss rates in both the sets (log-rank p < 0.001). In the patients exceeding the CCI ninth decile, 1-year graft survival rates were only 0.7% and 23.1% in training and validation sets, respectively. CCI shows a very good diagnostic power for 90-day and 1-year graft loss in different sets of patients, indicating better accuracy with respect to other pre- and post-LT scores.Clinical Trial Notification: NCT03723317.
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Lai, Q
-
Melandro, F
-
Nowak, G
-
Nicolini, D
-
Iesari, S
-
Fasolo, E
-
visa fler...
-
Mennini, G
-
Romano, A
-
Mocchegiani, F
-
Ackenine, K
-
Polacco, M
-
Marinelli, L
-
Ciccarelli, O
-
Zanus, G
-
Vivarelli, M
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Cillo, U
-
Rossi, M
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Ericzon, BG
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Lerut, J
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visa färre...
- Artiklar i publikationen
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Updates in surge ...
- Av lärosätet
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Karolinska Institutet